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Technical InfoEdit

Staining PatternEdit

  • Membranous, vesicular staining (not granular cytoplasmic staining) is indicative of intracellular lipids[1]

Expression in Normal TissuesEdit

Expression in Neoplastic EntitiesEdit

Tumor name % Positive Staining Number of Cases
Sebaceous adenoma[1] 100% 16/16
Xanthogranuloma[1] 90% 9/10
Xanthoma[1] 100% 6/6
Xanthelasma[1] 100% 10/10

Intermediate/Uncertain Malignant PotentialEdit
Tumor name % Positive Staining Number of Cases

Tumor name % Positive Staining Number of Cases
Sebaceous carcinoma[1] 92% 23/25
Metastatic renal cell carcinoma[1] 62.5% 9/13

Expression in Non-Neoplastic EntitiesEdit

Practical Uses / PanelsEdit

Common PitfallsEdit


  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Modern Pathology (2010) 23, 567–573

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