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Anaplastic Lymphoma Kinase (ALK-1)

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  • ALK-1 expression in anaplastic large cell lymphoma

SynonymsEdit

  • CD246

AntibodiesEdit

Technical InfoEdit

Staining PatternEdit

Expression in Normal TissuesEdit

Expression in Neoplastic EntitiesEdit

BenignEdit
Tumor name % Positive Staining Number of Cases
Inflammatory myofibroblastic tumor (IMT) 60%[1] 73[1] -


Intermediate/Uncertain Malignant PotentialEdit
Tumor name % Positive Staining Number of Cases


MalignantEdit
Tumor name % Positive Staining Number of Cases
Anaplastic large cell lymphoma (ALCL)

Expression in Non-Neoplastic EntitiesEdit

Pertinent NegativesEdit

This antigen is typically NOT expressed by the following entities:

Practical Uses / PanelsEdit

  • ALK-1 positivity in Anaplastic Large Cell Lymphoma (ALCL) has a favorable prognostic significance (80% 5 year survival vs 40% 5 year survival observed in ALK-1 negative ALCLs).

Common PitfallsEdit

Related Links/Other ResourcesEdit

ReferencesEdit

  1. 1.0 1.1 Am J Surg Pathol. 2001 Nov;25(11):1364-71.

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