• BCL-2 expression in solitary fibrous tumor.
  • BCL-2 expression in solitary fibrous tumor.
  • Bcl-2 expression in a cellular blue nevus.



Technical InfoEdit

Staining PatternEdit

Endoplasmic reticulum, nuclear envelope, and inner mitochondrial membrane.

Expression in Normal TissuesEdit

  • Lymphocytes in mantle zone and T cell areas of lymph nodes

Expression in Neoplastic EntitiesEdit

Tumor name % Positive Staining Number of Cases
Solitary Fibrous Tumor (Hemangiopericytoma) 100%[1] 16/16[1]
Cellular Blue Nevus[2]

Intermediate/Uncertain Malignant PotentialEdit
Tumor name % Positive Staining Number of Cases

Tumor name % Positive Staining Number of Cases
Synovial Sarcoma (including monophasic [MFSS] and poorly differentiated[PDSS])[3] MFSS 91%, PDSS 92%[3] MFSS 43/47, PDSS 12/13[3]
Follicular Lymphoma (Grade I, Grade II, Grade III) 97%, 83%, 74%[4] 107/110, 119/143, 71/96[4]
Clear cell sarcoma 94%[5] 30/32[5]

Expression in Non-Neoplastic EntitiesEdit

Pertinent NegativesEdit

This antigen is typically NOT expressed by the following entities:

Practical Uses / PanelsEdit

  • Follicular Lymphoma (positive germinal centers) vs. follicular/reactive hyperplasia (negative germinal centers)

Common PitfallsEdit

BCL-2 expression decreases with increasing grade in Follicular Lymphoma.

Laboratory Investigation (2004) 84, 235–244, advance online publication, 19 January 2004; doi:10.1038/labinvest.3700051

Related Links/Other ResourcesEdit


  1. 1.0 1.1 Am J Surg Pathol. 2001 Jul;25(7):900-10.
  2. J Cutan Pathol. 2001 Mar;28(3):145-50.
  3. 3.0 3.1 3.2 Am J Surg Pathol. 2002 Nov;26(11):1434-40.
  4. 4.0 4.1 Mod Pathol. 1998 Sep;11(9):864-9.
  5. 5.0 5.1 Am J Surg Pathol. 2008 Mar;32(3):452-60.

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