FANDOM


SynonymsEdit

EpCam

AntibodiesEdit

Technical InfoEdit

Staining PatternEdit

  • Membrane

Expression in Normal TissuesEdit

Expression in Neoplastic EntitiesEdit

BenignEdit
Tumor name % Positive Staining Number of Cases


Intermediate/Uncertain Malignant PotentialEdit
Tumor name % Positive Staining Number of Cases


MalignantEdit
Tumor name % Positive Staining Number of Cases
Pulmonary Adenocarcinoma 85%[1] 17/20[1]
Basal Cell Carcinoma[2]

Expression in Non-Neoplastic EntitiesEdit

Pertinent NegativesEdit

This antigen is typically NOT expressed by the following entities:

  • Malignant Mesothelioma
  • Squamous Cell Carcinoma

Practical Uses / PanelsEdit

  • Ber-EP4 can be used with other markers to differentiate Pulmonary Adenocarcinoma (Ber-EP4+) from Malignant Mesothelioma (Ber-EP4-).
  • Ber-EP4 can be used with other markers such as BCL-2 to differentiate squamoid Basal Cell Carcinoma (Ber-EP4+, BCL-2 +) from basaloid Squamous Cell Carcinoma (Ber-EP4-, BCL-2-).[2] Distinction is crucial in certain anatomic locations such as the perianal skin.

Common PitfallsEdit

Related Links/Other ResourcesEdit

ReferencesEdit

  1. 1.0 1.1 Am J Surg Pathol. 2001 Jan;25(1):43-50.
  2. 2.0 2.1 J Cutan Pathol. 1998 Mar;25(3):153-9.

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