Synonyms[]
EpCam
Antibodies[]
Technical Info[]
Staining Pattern[]
- Membrane
Expression in Normal Tissues[]
Expression in Neoplastic Entities[]
Benign[]
| Tumor name | % Positive Staining | Number of Cases |
Intermediate/Uncertain Malignant Potential[]
| Tumor name | % Positive Staining | Number of Cases |
Malignant[]
| Tumor name | % Positive Staining | Number of Cases |
| Pulmonary Adenocarcinoma | 85%[1] | 17/20[1] |
| Basal Cell Carcinoma[2] | ||
Expression in Non-Neoplastic Entities[]
Pertinent Negatives[]
This antigen is typically NOT expressed by the following entities:
- Malignant Mesothelioma
- Squamous Cell Carcinoma
Practical Uses / Panels[]
- Ber-EP4 can be used with other markers to differentiate Pulmonary Adenocarcinoma (Ber-EP4+) from Malignant Mesothelioma (Ber-EP4-).
- Ber-EP4 can be used with other markers such as BCL-2 to differentiate squamoid Basal Cell Carcinoma (Ber-EP4+, BCL-2 +) from basaloid Squamous Cell Carcinoma (Ber-EP4-, BCL-2-).[2] Distinction is crucial in certain anatomic locations such as the perianal skin.
Common Pitfalls[]
Related Links/Other Resources[]
References[]
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