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Brachyury

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  • Nuclear expression of brachyury in chordoma.
  • Nuclear expression of brachyury in chordoma.
  • Nuclear expression of brachyury in chordoma.
  • Nuclear expression of brachyury in chordoma.
  • Nuclear expression of brachyury in chordoma.
  • Nuclear expression of brachyury in chordoma.
  • Nuclear expression of brachyury in chordoma.
  • Nuclear expression of brachyury in chordoma.
  • Nuclear expression of brachyury in chordoma.
  • Nuclear expression of brachyury in chordoma.


SynonymsEdit

AntibodiesEdit

Technical InfoEdit

Staining PatternEdit

Expression in Normal TissuesEdit

  • Embryonal notochord [1]

Expression in Neoplastic EntitiesEdit

BenignEdit
Tumor name % Positive Staining Number of Cases


Intermediate/Uncertain Malignant PotentialEdit
Tumor name % Positive Staining Number of Cases


MalignantEdit
Tumor name % Positive Staining Number of Cases
Chordoma (including extra-axial type) 98%[1] 53/54[1]

Expression in Non-Neoplastic EntitiesEdit

Practical Uses / PanelsEdit

  • Brachyury can be used to differentiate chordomas(brachyury+) from chondroid tumors (brachyury-) when cytokeratin expresssion in chordomas is weak or patchy (a potential problem in needle biopsy).[1]

Common PitfallsEdit

ReferencesEdit

  1. 1.0 1.1 1.2 1.3 1.4 J Pathol. 2006 Jun;209(2):157-65.

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