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CD10

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  • CD10 expression in a primary cutaneous PEComa. This could potentially result in a misdiagnosis of metastatic renal cell carcinoma if PEComa was not considered in the differential.
  • CD10 expression in a primary cutaneous PEComa. This could potentially result in a misdiagnosis of metastatic renal cell carcinoma if PEComa was not considered in the differential.
  • CD10 expression in a primary cutaneous PEComa. This could potentially result in a misdiagnosis of metastatic renal cell carcinoma if PEComa was not considered in the differential.
  • CD10 staining normal germinal center B-cells.
  • CD10 staining normal germinal center B-cells.
  • Strong CD10 expression in a sarcomatoid squamous cell carcinoma. The tumor was also positive for cytokeratin and p63.
  • Strong CD10 expression in a sarcomatoid squamous cell carcinoma. The tumor was also positive for cytokeratin and p63.
  • Strong CD10 expression in a sarcomatoid squamous cell carcinoma. The tumor was also positive for cytokeratin and p63.
  • CD10 expression in epithelioid angiosarcoma.
  • CD10 expression in epithelioid angiosarcoma.
  • CD10 expression in normal placenta.
  • CD10 expression in normal placenta.
  • CD10 expression in a germinal center.
  • CD10 expression in proximal tubules of kidney.


SynonymsEdit

  • CALLA (Common Acute Lymphoblastic Leukemia Antigen)

AntibodiesEdit

Technical InfoEdit

Staining PatternEdit

  • Membranous

Expression in Normal TissuesEdit

  • Cytotrophoblasts[1]
  • Endometrial stroma
  • Germinal center B-cells
  • Myoepithelial cells[2]
  • Syncytiotrophoblasts[1]

Expression in Neoplastic EntitiesEdit

BenignEdit
Tumor name % Positive Staining Number of Cases
Myoepithelioma
Myoepithelial component of adenomyoepithelioma
Leiomyoma 20%[3] 2/10[3]


Intermediate/Uncertain Malignant PotentialEdit
Tumor name % Positive Staining Number of Cases
Epithelioid Hemangioendothelioma 78%[4] 7/9[4]
Trophoblasts in complete and partial moles[1]


MalignantEdit
Tumor name % Positive Staining Number of Cases
Atypical fibroxanthoma (AFX)
Choriocarcinoma[1]
Diffuse large B-cell lymphoma, germinal center type[5]
Epithelioid Angiosarcoma 67%[4] 2/3[4]
Follicular lymphoma 98%[6] 57/58[6]
Renal cell carcinoma (conventional, papillary) 94%, 93%[7] 58/62, 13/14[7]
Myoepithelial carcinoma
Endometrial Stromal Sarcoma 100%[3] 16/16[3]

Expression in Non-Neoplastic EntitiesEdit

  • Mesonephric remnants[1]

Practical Uses / PanelsEdit

  • Can be used as a part of a panel to differentiate Endometrial Stromal Sarcoma (CD10+) from Cellular Leiomyoma (usually CD10-)[3]
  • Can be used to differentiate metastatic Renal Cell Carcinoma of Conventional type (CD10+) from Hemangioblastoma (CD10-)[8]
  • Can be used to demonstrate the germinal center origin of Diffuse Large B Cell Lymphoma (if CD10+), which has a better prognosis [5]

Common PitfallsEdit

  • CD10 is very non-specific (50% of cellular leiomyomas and many leiomyosarcomas express CD10) for most spindle cell tumors, despite initial reports in the literature to the contrary.[9]
  • Despite initial reports, CD10 is not specific for atypical fibroxanthoma.

ReferencesEdit

  1. 1.0 1.1 1.2 1.3 1.4 Am J Surg Pathol. 2003 Feb;27(2):178-86.
  2. Mod Pathol. 2002 Apr;15(4):397-405.
  3. 3.0 3.1 3.2 3.3 3.4 Mod Pathol. 2001 May;14(5):465-71.
  4. 4.0 4.1 4.2 4.3 Arch Pathol Lab Med. 2009 Dec;133(12):1965-8.
  5. 5.0 5.1 Mod Pathol. 2005 Aug;18(8):1113-20.
  6. 6.0 6.1 Am J Clin Pathol. 2002 Feb;117(2):291-300.
  7. 7.0 7.1 Am J Surg Pathol. 2000 Feb;24(2):203-10.
  8. Mod Pathol. 2005 Jun;18(6):788-94.
  9. Am J Surg Pathol. 2002 Apr;26(4):403-12.

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