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CD20

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  • CD20 staining B-cells in germinal centers.
  • CD20 staining B-cells in germinal centers.
  • CD20 in Mantle Cell lymphoma
CD20 is an antigen expressed on the surface of B lymphocytes.

SynonymsEdit

AntibodiesEdit

Technical InfoEdit

Staining PatternEdit

Expression in Normal TissuesEdit

  • B lymphocytes

Expression in Neoplastic EntitiesEdit

BenignEdit
Tumor name % Positive Staining Number of Cases


Intermediate/Uncertain Malignant PotentialEdit
Tumor name % Positive Staining Number of Cases


MalignantEdit
Tumor name % Positive Staining Number of Cases
Diffuse large B-cell lyphoma (DLBCL)
Follicular lymphoma
Mantle cell lymphoma
Marginal zone lymphoma
Small cell lymphoma / Chronic lymphocytic leukemia (SLL/CLL)

Expression in Non-Neoplastic EntitiesEdit

Practical Uses / PanelsEdit

Common PitfallsEdit

- CD20 immunohistochemistry and immunophenotyping by flow cytometry may be falsely negative in patient's receiving or having recently received anti-CD20 therapy (i.e. Rituximab).

ReferencesEdit

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