CD21 (also known as complement receptor 2)[1] is an antigen that is expressed on the surface of B lymphocytes[2] and follicular dendritic cells.[3]



Technical InfoEdit

Staining PatternEdit

Expression in Normal TissuesEdit

  • B lymphocytes[2]
  • Follicular dendritic cells [3]

Expression in Neoplastic EntitiesEdit

Tumor name % Positive Staining Number of Cases

Intermediate/Uncertain Malignant PotentialEdit
Tumor name % Positive Staining Number of Cases

Tumor name % Positive Staining Number of Cases
Follicular dendritic cell tumors

Expression in Non-Neoplastic EntitiesEdit

Practical Uses / PanelsEdit

Common PitfallsEdit


  1. Frank K, Atkinson JP (2001). "Complement system." In Austen KF, Frank K, Atkinson JP, Cantor H. eds. Samter's Immunologic Diseases, 6th ed. Vol. 1, p. 281-298, Philadelphia: Lippincott Williams & Wilkins, ISBN 0781721202.
  2. 2.0 2.1 Entrez Gene: CR2 complement component (3d/Epstein Barr virus) receptor 2
  3. 3.0 3.1 J Exp Med. 1997 Jan 6;185(1):165-70.

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