• Low affinity IgE receptor
  • Fc fragment of IgE receptor
  • FCER


Technical InfoEdit

Staining PatternEdit

  • Cytoplasmic

Expression in Normal TissuesEdit

  • Activated mature B cells (Expressing IgM or IgD)
  • Activated monocytes
  • Activated macrophages
  • Platelets
  • Eosinophils
  • Langerhans cells
  • Follicular dendritic cells
  • Intestinal epithelium (IgE receptors)

Expression in Neoplastic EntitiesEdit

Tumor name % Positive Staining (Sensitivity) Specificity

Intermediate/Uncertain Malignant PotentialEdit
Tumor name % Positive Staining (Sensitivity) Specificity
Follicular dendritic cell tumor

Tumor name % Positive Staining (Sensitivity) Specificity
CLL/SLL[1] Nearly 100%
Mediastinal large B-cell lymphoma[2] 70%
Lymphoplasmacytic lymphoma[3] 61%
Hairy cell leukemia[4] 17%
Diffuse large B-cell lymphoma (DLBCL) 16%
Additional Comments:Edit

Expression in Non-Neoplastic EntitiesEdit

Pertinent NegativesEdit

This antigen is typically NOT expressed by the following entities:

  • Mantle cell lymphoma[1]
  • Burkitt's lymphoma
  • Burkitt-like lymphoma[5]
  • Follicular lymphoma
  • Marginal zone lymphoma[6]

Practical Uses / PanelsEdit

  • CLL/SLL vs Mantle cell lymphoma or MALT lymphoma

Common PitfallsEdit

Related Links/Other ResourcesEdit


  1. 1.0 1.1 Koiso H, Tsukamoto N, Miyawaki S, Shinonome S, Nojima Y, Karasawa M. Quantitative analysis of Cyclin D1 and CD23 expression in mantle cell lymphoma and B-chronic lymphocytic leukemia. Leuk Res 2002;26(9):809-15
  2. Calaminici M, Piper K, Lee AM, Norton AJ. CD23 expression in mediastinal large B-cell lymphomas. Histopathology 2004;45(6):619-24
  3. Konoplev S, Medeiros LJ, Bueso-Ramos CE, Jorgensen JL, Lin P. Immunophenotypic profile of lymphoplasmacytic lymphoma/Waldentrom macroglobulinemia. Am J Clin Pathol. 2005;124(3):414-20
  4. Chen YH, Tallman MS, Goolsby C, Peterson L. Immunophenotypic variations of hairy cell leukemia. Am J Clin Pathol. 2006;125(2):251-9
  5. McClure RF, Remstein ED, Macon WR, Dewald GW, Habermann TM, Hoering A, Kurtin PJ. Adult B-cell lymphomas with burkitt-like morphology are phenotypically and genotypically heterogeneous with aggressive clinical behavior. Am J Clin Pathol. 2005;29(12):1652-60
  6. Campo E, Miquel R, Krenacs L, Sorbara L, Raffeld M, Jaffe ES. Primary nodal marginal zone lymphomas of splenic and MALT type. Am J Clin Pathol. 1999;23(1):59-68

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