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CD23

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SynonymsEdit

  • Low affinity IgE receptor
  • Fc fragment of IgE receptor
  • FCER

AntibodiesEdit

Technical InfoEdit

Staining PatternEdit

  • Cytoplasmic

Expression in Normal TissuesEdit

  • Activated mature B cells (Expressing IgM or IgD)
  • Activated monocytes
  • Activated macrophages
  • Platelets
  • Eosinophils
  • Langerhans cells
  • Follicular dendritic cells
  • Intestinal epithelium (IgE receptors)

Expression in Neoplastic EntitiesEdit

BenignEdit
Tumor name % Positive Staining (Sensitivity) Specificity


Intermediate/Uncertain Malignant PotentialEdit
Tumor name % Positive Staining (Sensitivity) Specificity
Follicular dendritic cell tumor


MalignantEdit
Tumor name % Positive Staining (Sensitivity) Specificity
CLL/SLL[1] Nearly 100%
Mediastinal large B-cell lymphoma[2] 70%
Lymphoplasmacytic lymphoma[3] 61%
Hairy cell leukemia[4] 17%
Diffuse large B-cell lymphoma (DLBCL) 16%
Additional Comments:Edit

Expression in Non-Neoplastic EntitiesEdit

Pertinent NegativesEdit

This antigen is typically NOT expressed by the following entities:

  • Mantle cell lymphoma[1]
  • Burkitt's lymphoma
  • Burkitt-like lymphoma[5]
  • Follicular lymphoma
  • Marginal zone lymphoma[6]

Practical Uses / PanelsEdit

  • CLL/SLL vs Mantle cell lymphoma or MALT lymphoma

Common PitfallsEdit

Related Links/Other ResourcesEdit

ReferencesEdit

  1. 1.0 1.1 Koiso H, Tsukamoto N, Miyawaki S, Shinonome S, Nojima Y, Karasawa M. Quantitative analysis of Cyclin D1 and CD23 expression in mantle cell lymphoma and B-chronic lymphocytic leukemia. Leuk Res 2002;26(9):809-15
  2. Calaminici M, Piper K, Lee AM, Norton AJ. CD23 expression in mediastinal large B-cell lymphomas. Histopathology 2004;45(6):619-24
  3. Konoplev S, Medeiros LJ, Bueso-Ramos CE, Jorgensen JL, Lin P. Immunophenotypic profile of lymphoplasmacytic lymphoma/Waldentrom macroglobulinemia. Am J Clin Pathol. 2005;124(3):414-20
  4. Chen YH, Tallman MS, Goolsby C, Peterson L. Immunophenotypic variations of hairy cell leukemia. Am J Clin Pathol. 2006;125(2):251-9
  5. McClure RF, Remstein ED, Macon WR, Dewald GW, Habermann TM, Hoering A, Kurtin PJ. Adult B-cell lymphomas with burkitt-like morphology are phenotypically and genotypically heterogeneous with aggressive clinical behavior. Am J Clin Pathol. 2005;29(12):1652-60
  6. Campo E, Miquel R, Krenacs L, Sorbara L, Raffeld M, Jaffe ES. Primary nodal marginal zone lymphomas of splenic and MALT type. Am J Clin Pathol. 1999;23(1):59-68

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