Synonyms[]
- Low affinity IgE receptor
- Fc fragment of IgE receptor
- FCER
Antibodies[]
Technical Info[]
Staining Pattern[]
- Cytoplasmic
Expression in Normal Tissues[]
- Activated mature B cells (Expressing IgM or IgD)
- Activated monocytes
- Activated macrophages
- Platelets
- Eosinophils
- Langerhans cells
- Follicular dendritic cells
- Intestinal epithelium (IgE receptors)
Expression in Neoplastic Entities[]
Benign[]
| Tumor name | % Positive Staining (Sensitivity) | Specificity |
Intermediate/Uncertain Malignant Potential[]
| Tumor name | % Positive Staining (Sensitivity) | Specificity |
| Follicular dendritic cell tumor | ||
Malignant[]
| Tumor name | % Positive Staining (Sensitivity) | Specificity |
| CLL/SLL[1] | Nearly 100% | |
| Mediastinal large B-cell lymphoma[2] | 70% | |
| Lymphoplasmacytic lymphoma[3] | 61% | |
| Hairy cell leukemia[4] | 17% | |
| Diffuse large B-cell lymphoma (DLBCL) | 16% | |
Additional Comments:[]
Expression in Non-Neoplastic Entities[]
Pertinent Negatives[]
This antigen is typically NOT expressed by the following entities:
- Mantle cell lymphoma[1]
- Burkitt's lymphoma
- Burkitt-like lymphoma[5]
- Follicular lymphoma
- Marginal zone lymphoma[6]
Practical Uses / Panels[]
- CLL/SLL vs Mantle cell lymphoma or MALT lymphoma
Common Pitfalls[]
Related Links/Other Resources[]
References[]
- ↑ 1.0 1.1 Koiso H, Tsukamoto N, Miyawaki S, Shinonome S, Nojima Y, Karasawa M. Quantitative analysis of Cyclin D1 and CD23 expression in mantle cell lymphoma and B-chronic lymphocytic leukemia. Leuk Res 2002;26(9):809-15
- ↑ Calaminici M, Piper K, Lee AM, Norton AJ. CD23 expression in mediastinal large B-cell lymphomas. Histopathology 2004;45(6):619-24
- ↑ Konoplev S, Medeiros LJ, Bueso-Ramos CE, Jorgensen JL, Lin P. Immunophenotypic profile of lymphoplasmacytic lymphoma/Waldentrom macroglobulinemia. Am J Clin Pathol. 2005;124(3):414-20
- ↑ Chen YH, Tallman MS, Goolsby C, Peterson L. Immunophenotypic variations of hairy cell leukemia. Am J Clin Pathol. 2006;125(2):251-9
- ↑ McClure RF, Remstein ED, Macon WR, Dewald GW, Habermann TM, Hoering A, Kurtin PJ. Adult B-cell lymphomas with burkitt-like morphology are phenotypically and genotypically heterogeneous with aggressive clinical behavior. Am J Clin Pathol. 2005;29(12):1652-60
- ↑ Campo E, Miquel R, Krenacs L, Sorbara L, Raffeld M, Jaffe ES. Primary nodal marginal zone lymphomas of splenic and MALT type. Am J Clin Pathol. 1999;23(1):59-68