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  • CD30 expression by Reed-Sternberg and Hodgkin cells in classical Hodgkin lymphoma.
  • CD30 expression by Reed-Sternberg and Hodgkin cells in classical Hodgkin lymphoma.
  • CD30 expression by Reed-Sternberg and Hodgkin cells in classical Hodgkin lymphoma.
  • CD30 expression in embryonal carcinoma of the testis.


SynonymsEdit

  • Ki-1

AntibodiesEdit

Technical InfoEdit

Staining PatternEdit

  • Membranous and Golgi (perinuclear dot-like) (in Anaplastic Large Cell Lymphoma)

Expression in Normal TissuesEdit

Expression in Neoplastic EntitiesEdit

BenignEdit
Tumor name % Positive Staining Number of Cases


Intermediate/Uncertain Malignant PotentialEdit
Tumor name % Positive Staining Number of Cases


MalignantEdit
Tumor name % Positive Staining Number of Cases
Anaplastic Large Cell Lymphoma (ALCL)
CD30+ Diffuse Large B-cell Lymphoma (DLBCL)
Primary Mediastinal Diffuse Large B-cell Lymphoma
Embryonal Carcinoma[1][2]
Hodgkin Lymphoma (stains Reed-Sternberg cells)
Primary Cutaneous Anaplastic Large Cell Lymphoma (PC-ALCL)
Lymphomatoid Papulosis (LyP)

Expression in Non-Neoplastic EntitiesEdit

Practical Uses / PanelsEdit

  • Leroy et al suggested that CD30 and CD117 (ckit) used together as a panel was useful for distinguishing seminoma from embryonal carcinoma. Seminoma should be CD30-/CD117+ but embryonal carcinoma should be CD30+/CD117-. The expression of one marker when the other was absent was considered specific.[2]

Common PitfallsEdit

ReferencesEdit

  1. 1.0 1.1 Am J Pathol. 1988 December; 133(3): 446–450.
  2. 2.0 2.1 Journal of Histochemistry and Cytochemistry, Vol. 50, 283-286, February 2002

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