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CD31

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  • CD31 expression in epithelioid hemangioendothelioma of the liver.
  • CD31 expression in epithelioid hemangioendothelioma of the liver.
  • CD31 expression in epithelioid hemangioendothelioma of the liver.
  • CD31 expression in epithelioid hemangioendothelioma of the liver.
  • CD31 expression in epithelioid hemangioendothelioma of the liver.
  • CD31 expression in epithelioid hemangioendothelioma of the liver.
  • CD31 expression in epithelioid hemangioendothelioma of the liver.
  • Membranous CD31 expression in cutaneous epithelioid angiosarcoma.
  • Membranous CD31 expression in cutaneous epithelioid angiosarcoma.
  • Membranous CD31 expression in cutaneous epithelioid angiosarcoma.
  • CD31 expression in spindle cell angiosarcoma metastatic to the lung.
  • CD31 expression in spindle cell angiosarcoma metastatic to the lung.
  • CD31 expression in spindle cell angiosarcoma metastatic to the lung.
  • CD31 expression in spindle cell angiosarcoma metastatic to the lung.
  • CD31 expression in vascular and lymphatic endothelium in a benign lymph node.
  • CD31 is often expressed by normal histiocytes.
  • CD31 is often expressed by normal histiocytes.


SynonymsEdit

  • PECAM-1

AntibodiesEdit

Technical InfoEdit

Staining PatternEdit

  • Membranous

Expression in Normal TissuesEdit

  • Highly sensitive and specific for endothelium of blood vessels and lymphatics
  • May be expressed by normal histiocytes

Expression in Neoplastic EntitiesEdit

BenignEdit
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments
Hemangioma (all types) 100% 13
Lymphangioma 91% 33


Intermediate/Uncertain Malignant PotentialEdit
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments
Atypical vascular lesion (AVL) of breast (post-radiation)
Hemangioendothelioma (all types)
Epithelioid sarcoma-like hemangioendothelioma (Note: negative for CD34)


MalignantEdit
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments
Angiosarcoma

Expression in Non-Neoplastic EntitiesEdit

  • Vascular malformations

Pertinent NegativesEdit

CD31 is typically NOT expressed in the following:

  • Most carcinomas (NOTE: carcinomas can sometimes express CD31)

Practical Uses / PanelsEdit

Can be used to indicate the vascular origin of tumors

Common PitfallsEdit

  • Collections of CD31 positive histiocytes may be mistaken for a vascular neoplasm.
  • Plasma cells and some activated T- and B- lymphocytes may also exhibit moderate to strong membranous reaction.

ReferencesEdit

Bhawan J, Silva C, Taungiaruwinai WM. Inconsistent immunohistochemical expression of lymphatic and blood endothelial cell markers in cutaneous lymphangiomas. J Cutan Pathol 2013 Sep;40(9): 801-6.

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