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  • CD34 expression in dermatofibrosarcoma protuberans (DFSP). Note the "honeycomb" pattern of fat entrapment.
  • CD34 expression in dermatofibrosarcoma protuberans (DFSP). Note the "honeycomb" pattern of fat entrapment.
  • CD34 expression in dermatofibrosarcoma protuberans (DFSP). Note the "honeycomb" pattern of fat entrapment.
  • CD34 expression in dermatofibrosarcoma protuberans (DFSP). Note the "honeycomb" pattern of fat entrapment.
  • CD34 expression in dermatofibrosarcoma protuberans (DFSP). Note the "honeycomb" pattern of fat entrapment.
  • CD34 expression in dermatofibrosarcoma protuberans (DFSP). Note the "honeycomb" pattern of fat entrapment.
  • CD34 expression in dermatofibrosarcoma protuberans (DFSP). Note the "honeycomb" pattern of fat entrapment.
  • CD34 expression in dermatofibrosarcoma protuberans (DFSP).
  • CD34 expression in solitary fibrous tumor (hemangiopericytoma)(SFT/HPC).
  • CD34 expression in solitary fibrous tumor (hemangiopericytoma)(SFT/HPC).
  • CD34 expression in epithelioid hemangioendothelioma of liver.
  • CD34 expression in epithelioid hemangioendothelioma of liver.
  • CD34 expression in epithelioid hemangioendothelioma of liver.
  • CD34 expression in epithelioid hemangioendothelioma of liver.
  • CD34 expression in epithelioid hemangioendothelioma of liver.
  • CD34 expression in epithelioid hemangioendothelioma of liver.
  • CD34 expression in epithelioid hemangioendothelioma of liver.
  • CD34 expression in epithelioid hemangioendothelioma of liver.
  • CD34 expression in mammary myofibroblastoma.
  • CD34 expression in mammary myofibroblastoma.


SynonymsEdit

AntibodiesEdit

Technical InfoEdit

Staining PatternEdit

Expression in Normal TissuesEdit

  • Vascular endothelium
  • Dermal spindle cells
  • Adventitial spindle cells (around cutaneous adnexal structures such as hair follicles, sweat ducts, etc).

Expression in Neoplastic EntitiesEdit

BenignEdit
Tumor name % Positive Staining Number of Cases
Benign vascular tumors (hemangiomas, etc)
Spindle cell / pleomorphic lipoma
Mammary-type myofibroblastoma
Neurofibroma
Perineurioma
Schwannoma
Cellular angiofibroma (aka so-called angiomyofibroblastoma-like tumor of the male genital tract)
Intermediate/Uncertain Malignant PotentialEdit
Tumor name % Positive Staining Number of Cases
Epithelioid Hemangioendothelioma
Kaposiform Hemangioendothelioma
Dabska Hemangioendothelioma
Solitary fibrous tumor 100%[1] 16/16[1]
MalignantEdit
Tumor name % Positive Staining Number of Cases
Kaposi sarcoma
Angiosarcoma
Dermatofibrosarcoma protuberans (DFSP)
Well differentiated liposarcoma
Epithelioid sarcoma (classic and proximal type)

Expression in Non-Neoplastic EntitiesEdit

Practical Uses / PanelsEdit

  • Can be used to differentiate Solitary Fibrous Tumor (CD34+) from Desmoplastic Mesothelioma (CD34-)[2]
  • Neurofibroma vs. Desmoplastic Melanoma[3]

Pertinent NegativesEdit

This antigen is typically NOT expressed by the following entities:

Common PitfallsEdit

  • Fibrous histiocytoma (dermatofibroma) may occasional express CD34. Also, they often show enhanced CD34 expression at periphery of the lesion that may be mistaken for actual CD34 staining.

ReferencesEdit

  1. 1.0 1.1 Am J Surg Pathol. 2001 Jul;25(7):900-10.
  2. Hum Pathol. 1995 Apr;26(4):428-31.
  3. Yeh I, McCalmont TH. Distinguishing neurofibroma from desmoplastic melanoma: the value of the CD34 imprint. J Cutan Pathol. 2011

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