CD34 expression in dermatofibrosarcoma protuberans (DFSP). Note the "honeycomb" pattern of fat entrapment.
CD34 expression in dermatofibrosarcoma protuberans (DFSP). Note the "honeycomb" pattern of fat entrapment.
CD34 expression in dermatofibrosarcoma protuberans (DFSP). Note the "honeycomb" pattern of fat entrapment.
CD34 expression in dermatofibrosarcoma protuberans (DFSP). Note the "honeycomb" pattern of fat entrapment.
CD34 expression in dermatofibrosarcoma protuberans (DFSP). Note the "honeycomb" pattern of fat entrapment.
CD34 expression in dermatofibrosarcoma protuberans (DFSP). Note the "honeycomb" pattern of fat entrapment.
CD34 expression in dermatofibrosarcoma protuberans (DFSP). Note the "honeycomb" pattern of fat entrapment.
CD34 expression in dermatofibrosarcoma protuberans (DFSP).
CD34 expression in solitary fibrous tumor (hemangiopericytoma)(SFT/HPC).
CD34 expression in solitary fibrous tumor (hemangiopericytoma)(SFT/HPC).
CD34 expression in epithelioid hemangioendothelioma of liver.
CD34 expression in epithelioid hemangioendothelioma of liver.
CD34 expression in epithelioid hemangioendothelioma of liver.
CD34 expression in epithelioid hemangioendothelioma of liver.
CD34 expression in epithelioid hemangioendothelioma of liver.
CD34 expression in epithelioid hemangioendothelioma of liver.
CD34 expression in epithelioid hemangioendothelioma of liver.
CD34 expression in epithelioid hemangioendothelioma of liver.
CD34 expression in mammary myofibroblastoma.
CD34 expression in mammary myofibroblastoma.
Synonyms [ ]
Antibodies [ ]
Technical Info [ ]
Staining Pattern [ ]
Expression in Normal Tissues [ ]
Vascular endothelium
Dermal spindle cells
Adventitial spindle cells (around cutaneous adnexal structures such as hair follicles, sweat ducts, etc).
Expression in Neoplastic Entities [ ]
Benign [ ]
Tumor name
% Positive Staining
Number of Cases
Benign vascular tumors (hemangiomas, etc)
Spindle cell / pleomorphic lipoma
Mammary-type myofibroblastoma
Neurofibroma
Perineurioma
Schwannoma
Cellular angiofibroma (aka so-called angiomyofibroblastoma-like tumor of the male genital tract)
Intermediate/Uncertain Malignant Potential [ ]
Tumor name
% Positive Staining
Number of Cases
Epithelioid Hemangioendothelioma
Kaposiform Hemangioendothelioma
Dabska Hemangioendothelioma
Solitary fibrous tumor
100%[1]
16/16[1]
Malignant [ ]
Tumor name
% Positive Staining
Number of Cases
Kaposi sarcoma
Angiosarcoma
Dermatofibrosarcoma protuberans (DFSP)
Well differentiated liposarcoma
Epithelioid sarcoma (classic and proximal type)
Expression in Non-Neoplastic Entities [ ]
Practical Uses / Panels [ ]
Can be used to differentiate Solitary Fibrous Tumor (CD34+) from Desmoplastic Mesothelioma (CD34-)[2]
Neurofibroma vs. Desmoplastic Melanoma[3]
Pertinent Negatives [ ]
This antigen is typically NOT expressed by the following entities:
Common Pitfalls [ ]
Fibrous histiocytoma (dermatofibroma) may occasional express CD34. Also, they often show enhanced CD34 expression at periphery of the lesion that may be mistaken for actual CD34 staining.
References [ ]