CD68 is a lysosomal glycoprotein that is expressed in monocytes/macrophages/histiocytes,  as well as in other cells containing lysosomes.
Expression in Normal TissuesEdit
Expression in Neoplastic EntitiesEdit
- Expressed in many high grade sarcomas.
Expression in Non-Neoplastic EntitiesEdit
Practical Uses / PanelsEdit
- Antibodies against CD68 may stain any cell containing lysosomes, and, thus, it is not specific for histiocytic lineage in high grade sarcomas and other tumors.