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CD79a

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  • CD79a expression in mantle zone B cells in a germinal center.
  • CD79a expression in a lymph node. Note stronger staining on mantle zone B cells and weaker staining on germinal center B cells.
  • CD79a expression in a lymph node. Note stronger staining on mantle zone B cells and weaker staining on germinal center B cells.

SynonymsEdit

  • MB-1

AntibodiesEdit

Technical InfoEdit

Staining PatternEdit

Expression in Normal TissuesEdit

  • B lymphocytes and plasma cells. [1] (mantle zone B cells typically show stronger CD79a expression than germinal center B cells)

Expression in Neoplastic EntitiesEdit

  • Benign
  • Intermediate/Uncertain Malignant Potential
  • Malignant

Expression in Non-Neoplastic EntitiesEdit

Pertinent NegativesEdit

Practical Uses / PanelsEdit

  • Is considered a "pan-B cell" marker because it is expressed from immature pre-B lymphocytes to mature B lymphocytes and even to plasma cells. In contrast, CD20 is considered a mature B cell marker since its not expressed on immature precursor cells; CD20 expression is lost in differentiation from a mature B lymphocyte to a plasma cell.[1]
  • Used to identify B lymphocytes after Rituximab (anti-CD20 antibody) has been administered for treating B cell lymphomas (B lyphocytes do not reliably stain CD20 after Rituximab use)[1] [2]

Common PitfallsEdit

Related Links/Other ResourcesEdit

ReferencesEdit

  1. 1.0 1.1 1.2 Appl Immunohistochem Mol Morphol. 2001 Jun;9(2):97-106.
  2. Am J Surg Pathol. 2005 Oct;29(10):1399-403.

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