FANDOM


  • Strong, diffuse CD99 expression in Ewing sarcoma / Primitive neuroectodermal tumor (PNET).
  • Strong, diffuse CD99 expression in Ewing sarcoma / Primitive neuroectodermal tumor (PNET).

SynonymsEdit

  • Ewing Sarcoma Marker
  • Cluster of Differentiation 99
  • MIC2
  • Single-chain type-1 glycoprotein

AntibodiesEdit

  • O-13

Technical InfoEdit

Staining PatternEdit

  • membranous

Expression in Normal TissuesEdit

  • Endothelial cells
  • Lymphocytes[1]

Expression in Neoplastic EntitiesEdit

BenignEdit
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments
Solitary Fibrous Tumor 85

%[2]

12/16[2]


Intermediate/Uncertain Malignant PotentialEdit
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments


MalignantEdit
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments
Synovial Sarcoma (including monophasic [MFSS] and poorly differentiated[PDSS]) MFSS 91%[3], PDSS 100%[3] MFSS 43/47, PDSS 13/13[3]
Ewing sarcoma / Primitive neuroectodermal tumor (PNET). 100%[4] 17/17[4]
Chloroma (Cutaneous AML) 55%[5] 6/11[5]
Acute Myelogenous Leukemia (AML) 43%[5] 13/30[5]

Expression in Non-Neoplastic EntitiesEdit

Pertinent NegativesEdit

This antigen is typically NOT expressed by the following entities:

  • NEGATIVE in neuroblastoma.
  • NEGATIVE in desmoplastic small round cell tumor (DSRCT)

Practical Uses / PanelsEdit

Common PitfallsEdit

  • Very sensitive for Ewings/PNET but not specific. Stains many round blue cell tumors including Lymphoblastic lymphoma[4].

Related Links/Other ResourcesEdit

ReferencesEdit

  1. J Korean Med Sci. 1999 Dec;14(6):600-6.
  2. 2.0 2.1 Am J Surg Pathol. 2001 Jul;25(7):900-10.
  3. 3.0 3.1 3.2 Am J Surg Pathol. 2002 Nov;26(11):1434-40.
  4. 4.0 4.1 4.2 Am J Clin Pathol. 2001 Jan;115(1):11-7.
  5. 5.0 5.1 5.2 5.3 Mod Pathol 2000;13(4):452–458

Ad blocker interference detected!


Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers

Wikia is not accessible if you’ve made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected.