• Nuclear CDK4 expression in dedifferentiated liposarcoma.
  • Nuclear CDK4 expression in dedifferentiated liposarcoma.
  • Nuclear CDK4 expression in dedifferentiated liposarcoma.



Technical InfoEdit

Staining PatternEdit

  • Nuclear

Expression in Normal TissuesEdit

Expression in Neoplastic EntitiesEdit


Intermediate/Uncertain Malignant PotentialEdit

  • Atypical lipomatous neoplasm (tumor) / Well differentiated liposarcoma
  • Dedifferentiated Liposarcoma
  • Parosteal osteosarcoma[1]

Expression in Non-Neoplastic EntitiesEdit

Pertinent NegativesEdit

This antigen is typically NOT expressed by the following entities:

  • Benign lipomatous tumors[2]

Practical Uses / PanelsEdit

  • Can be used with MDM2 to differentiate well differentiated liposarcoma (CDK4+, MDM2+) from benign adipose tumors (CDK4-, MDM2-)[3][2]
  • Can be used to distinguish dedifferentiated liposarcoma (CDK4+) from poorly differentiated sarcomas (CDK4-)[3]

Common PitfallsEdit

Related Links/Other ResourcesEdit


  1. Takashi Tsuchiyaa, Ki-ichi Sekineb, Shin-ichi Hinoharab, Takeshi Namikia, c, Tsutomu Noboria, c and Yasuhiko Kaneko. Analysis of the p16INK4, p14ARF, p15, TP53, and MDM2 Genes and Their Prognostic Implications in Osteosarcoma and Ewing Sarcoma. Cancer Genetics and Cytogenetics. Volume 120, Issue 2, 15 July 2000, Pages 91-98.
  2. 2.0 2.1 Aleixo PB, Hartmann AA, Menezes IC, Meurer RT, Oliveira AM. Can MDM2 and CDK4 make the diagnosis of well differentiated/dedifferentiated liposarcoma? An immunohistochemical study on 129 soft tissue tumours. J Clin Pathol. 2009 Dec;62(12):1127-35.
  3. 3.0 3.1 Am J Surg Pathol. 2005 Oct;29(10):1340-7.

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