Technical InfoEdit

Staining PatternEdit

  • Nuclear

Expression in Normal TissuesEdit

  • Colonic epithelium

Expression in Neoplastic EntitiesEdit

Tumor name % Positive Staining Number of Cases

Intermediate/Uncertain Malignant PotentialEdit
Tumor name % Positive Staining Number of Cases

Tumor name % Positive Staining Number of Cases
Colonic Adenocarcinoma[1] 85.7%[1] 950/1109[1]
Ampullary Adenocarcinoma[1] 79%[1] 19/24[1]

Expression in Non-Neoplastic EntitiesEdit

Pertinent NegativesEdit

This antigen is typically NOT expressed by the following entities:

  • Breast carcinoma[2]

Practical Uses / PanelsEdit

  • Can help differentiate between ampullary adenocarcinoma (usually CDX2+) from cholangiocarcinoma (usually CDX2-)[1]
  • When used with villin can help differentiate between primary adenocarcinoma of bladder (CDX2-, villin-) from secondary adenocarcinoma of colon (CDX2+, villin+)[3]

Common PitfallsEdit

  • CDX2 is not invariably expressed by metastases of a CDX2+ primary tumor.[1]
  • CDX2 expression diminishes with higher grade and stage tumors.[1]

Related Links/Other ResourcesEdit


  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Kaimaktchiev V, Terraciana L, Tornillo L, Spichtin H, Stoios D, Bundi M, Korcheva V, Mirlacher M, Loda M, Sauter G, Corless CL. The homeobox intestinal differentiation factor CDX2 is selectively expressed in gastrointestinal adenocarcinomas. Mod Pathol. 2004;17:1392-9
  2. Arch Pathol Lab Med. 2005 Mar;129(3):338-47.
  3. Mod Pathol. 2005 Sep;18(9):1217-22.

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