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Carcinoembryonic Antigen (CEA)

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SynonymsEdit

AntibodiesEdit

Technical InfoEdit

Staining PatternEdit

Expression in Normal TissuesEdit

Expression in Neoplastic EntitiesEdit

BenignEdit
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments


Intermediate/Uncertain Malignant PotentialEdit
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments


MalignantEdit
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments
Adenocarcinomas
Hepatocellular Carcinoma (polyclonal CEA or pCEA) 93[1]-96%[2] 39/42[1], 24/25[2]
Additional Comments:Edit
  • CEA is positive in adenocarcinomas from a variety of origins including: lung, colon, stomach, biliary system, pancreas, sweat glands and breast.

Expression in Non-Neoplastic EntitiesEdit

Pertinent NegativesEdit

This antigen is typically NOT expressed by the following entities:

  • Adenocarcinomas arising from prostate, adrenal, kidney and endometrium
  • Serous ovarian tumors
  • Malignant Mesothelioma
  • Epithelioid Hemangioendothelioma

Practical Uses / PanelsEdit

  • Polyclonal CEA and monoclonal CEA when used with MOC31 and CD10 can help differentiate between Hepatocellular carcinoma (pCEA+, mCEA-, MOC31-, CD10%+) from cholangiocarcinoma (pCEA+, mCEA+, MOC31+, CD10-) and metastatic carcinoma (pCEA+, mCEA+, MOC31+, CD10-) although CD10 inclusion in the panel has been put into question due to the low sensitivity for Hepatocellular carcinoma (13/25 cases positive).[1][2]

Common PitfallsEdit

Related Links/Other ResourcesEdit

ReferencesEdit

  1. 1.0 1.1 1.2 Hum Pathol. 2002 Dec;33(12):1175-81.
  2. 2.0 2.1 2.2 Mod Pathol. 2002 Dec;15(12):1279-87.

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