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  • Metastatic endocrine neoplasm in the liver staining positive for Chromogranin A.
  • Metastatic endocrine neoplasm in the liver staining positive for Chromogranin A.
  • Chromogranin staining normal adrenal medulla. Note that the adrenal cortex does not stain.
  • Chromogranin staining normal adrenal medulla. Note that the adrenal cortex does not stain.


SynonymsEdit

AntibodiesEdit

Technical InfoEdit

Staining PatternEdit

Expression in Normal TissuesEdit

  • Pancreatic Islets of Langerhans

Expression in Neoplastic EntitiesEdit

BenignEdit
IntermediateEdit
MalignantEdit

Expression in Non-Neoplastic EntitiesEdit

Practical Uses / PanelsEdit

Chromogranin can be used to with calretinin, inhibin and melan-A to distinguish adrenal cortical lesions (chromogranin -, calretinin+, inhibin+, melan-A+) from adrenal medullary lesions (pheochromocytomas; chromogranin+, calretinin-, inhibin-, melan-A-). [1] Synaptophysin is not as specific as chromogranin when determining the origin of adrenal tumors (cortical vs medullary) since synaptophysin can stain adrenal cortical tumors as well as medullary tumors.

Chromogranin can be used with synaptophysin and CD56 to identify neuroendocrine tumors.

Common PitfallsEdit

ReferencesEdit

  1. [Am J Surg Pathol. 2010 Mar;34(3):423-32.]

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