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Claudin-1

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  • Cytoplasmic streamers in perineurioma.
  • Claudin-1 highlighting whorls in perineurioma.
  • Claudin-1 highlighting whorls in perineurioma.


SynonymsEdit

AntibodiesEdit

Technical InfoEdit

Staining PatternEdit

Expression in Normal TissuesEdit

  • Perineurial cells
  • Meningothelial cells

Expression in Neoplastic EntitiesEdit

BenignEdit
Tumor name % Positive Staining Number of Cases
Perineurioma
Meningioma


Intermediate/Uncertain Malignant PotentialEdit
Tumor name % Positive Staining Number of Cases


MalignantEdit
Tumor name % Positive Staining Number of Cases
Low-Grade Fibromyxoid Sarcoma

Expression in Non-Neoplastic EntitiesEdit

Practical Uses / PanelsEdit

Common PitfallsEdit

  • Claudin-1 is positive in low-grade fibromyxosarcoma and this, coupled with positivity for EMA, may lead to a misdiagnosis of perineurioma. GLUT-1 can help distinguish between these two entities with perineurioma usually positive and low-grade fibromyxosarcoma usually negative.

ReferencesEdit

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