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  • Focal CK7 expression in epithelioid hemangioendothelioma of the liver. Note the strong staining of the adjacent bile duct.
  • CK7 expression in epithelioid hemangioendothelioma of the liver.
  • Focal CK7 expression in epithelioid hemangioendothelioma of the liver. Note the strong staining of the adjacent bile duct.
  • CK7 expression in epithelioid hemangioendothelioma of the liver.
  • CK7 expression in epithelioid hemangioendothelioma of the liver.
  • CK7 expression in epithelioid hemangioendothelioma of the liver.
  • Cytokeratin 7 expression in benign bile ducts.
  • Cytokeratin 7 expression in proliferating bile ductules.
  • Cytokerating 7 expression in lung with lambertosis.
  • Cytokerating 7 expression in lung with lambertosis.
  • CK 7 highlighting the neoplastic cells in Paget's disease of the breast

SynonymsEdit

AntibodiesEdit

Technical InfoEdit

Staining PatternEdit

  • Cytoplasmic staining

Expression in Normal TissuesEdit

  • Bile ducts[1]
  • Pancreatic ducts [2]

Expression in Neoplastic EntitiesEdit

BenignEdit
Tumor name % Positive Staining Number of Cases


Intermediate/Uncertain Malignant PotentialEdit
Tumor name % Positive Staining Number of Cases


MalignantEdit
Tumor name % Positive Staining Number of Cases
Renal cell carcinoma (papillary, chromophobe) 95%, 100%[3] 19/20, 11/11[3]
Pulmonary adenocarcinoma and a subset of pulmonary squamous cell carcinoma
Carcinomas of the breast, thyroid, salivary glands, endometrium
Mesothelioma
A subset of gastric carcinomas
A subset of esophageal carcinomas

Expression in Non-Neoplastic EntitiesEdit

Pertinent NegativesEdit

This antigen is typically NOT expressed by the following entities:

Practical Uses / PanelsEdit

Common PitfallsEdit

  • Epithelioid hemangioendothelioma and angiosarcoma can both express cytokeratins, including CK 7, and this can lead to a misdiagnosis of carcinoma. Use of CD31 and CD34 can help with this distinction, as both markers are usually negative in carcinomas.

Related Links/Other ResourcesEdit

ReferencesEdit

  1. Histopathology. 2010 Mar;56(4):415-25.
  2. J Pathol. 1998 Mar;184(3):234-9.
  3. 3.0 3.1 Am J Clin Pathol. 2007 Feb;127(2):225-9.

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