• Podoplanin


Technical InfoEdit

Staining PatternEdit

Expression in Normal TissuesEdit

  • Lymphatic endothelium
  • Mesothelium
  • Myoepithelial cells[1]

Expression in Neoplastic EntitiesEdit

Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments
Fibrous Histiocytoma (Dermatofibroma) 100%[2] 56/56[2]
Adenomatoid Tumor

Intermediate/Uncertain Malignant PotentialEdit
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments
Well differentiated papillary mesothelioma
Atypical Vascular Lesion (see below)

Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments
Malignant Mesothelioma

Additional InformationEdit
  • Fibrous Histiocytoma (Dermatofibroma): Dermatofibroma has been reported to strongly and diffusely express D2-40 in 100% of cases (n=56) versus only occasional weak, patchy staining in Dermatofibrosarcoma Protuberans (DFSP). [2]

  • Atypical Vascular Lesion is a post-irradiation vascular proliferation with lymphatic phenotype. These may be precursors to angiosarcoma.

Expression in Non-Neoplastic EntitiesEdit

Practical Uses / PanelsEdit

D2-40 can be used in a panel with factor XIIIa and CD34 to differentiate between DFSP (D2-40-, factorXIIIa-, CD34+) and dermatofibroma (D2-40+, factorXIIIa+, CD34-).[2]

Common PitfallsEdit

  • Since D2-40 stains myoepithelial cells, D2-40 positivity may lead to the erroneous diagnosis of intralymphatic carcinoma in the presence of in-situ carcinoma in breast specimens.[1]


  1. 1.0 1.1 Rabban JT, Chen YY. D2-40 expression by breast myoepithelium: potential pitfalls in distinguishing intralymphatic carcinoma from in situ carcinoma. Hum Pathol. 2008 Feb;39(2):175-83.
  2. 2.0 2.1 2.2 2.3 Modern Pathology (2010) 23, 434–438

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