Synonyms[]
- Podoplanin
Antibodies[]
Technical Info[]
Staining Pattern[]
Expression in Normal Tissues[]
- Lymphatic endothelium
- Mesothelium
- Myoepithelial cells[1]
Expression in Neoplastic Entities[]
Benign[]
| Tumor name | % Positive Staining (Sensitivity) | Number of Cases | Specificity | Comments |
| Fibrous Histiocytoma (Dermatofibroma) | 100%[2] | 56/56[2] | ||
| Lymphangioma | ||||
| Adenomatoid Tumor | ||||
Intermediate/Uncertain Malignant Potential[]
| Tumor name | % Positive Staining (Sensitivity) | Number of Cases | Specificity | Comments |
| Well differentiated papillary mesothelioma | ||||
| Atypical Vascular Lesion (see below) | ||||
Malignant[]
| Tumor name | % Positive Staining (Sensitivity) | Number of Cases | Specificity | Comments |
| Malignant Mesothelioma | ||||
| Angiosarcoma | ||||
Additional Information[]
- Fibrous Histiocytoma (Dermatofibroma): Dermatofibroma has been reported to strongly and diffusely express D2-40 in 100% of cases (n=56) versus only occasional weak, patchy staining in Dermatofibrosarcoma Protuberans (DFSP). [2]
- Atypical Vascular Lesion is a post-irradiation vascular proliferation with lymphatic phenotype. These may be precursors to angiosarcoma.
Expression in Non-Neoplastic Entities[]
Practical Uses / Panels[]
D2-40 can be used in a panel with factor XIIIa and CD34 to differentiate between DFSP (D2-40-, factorXIIIa-, CD34+) and dermatofibroma (D2-40+, factorXIIIa+, CD34-).[2]
Common Pitfalls[]
- Since D2-40 stains myoepithelial cells, D2-40 positivity may lead to the erroneous diagnosis of intralymphatic carcinoma in the presence of in-situ carcinoma in breast specimens.[1]