Discovered on GIST 1
Membranous (epithelioid GIST)
Cytoplasmic (spindle cell GIST)
Expression in Normal TissuesEdit
Normal epithelium of breast, salivary glands, stomach, prostate, liver, testis, pancreas, gallbladder and normal interstitial cells of Cajal.
Expression in Neoplastic EntitiesEdit
High specificity: Gastrointestinal stromal tumors
Rare positivity reported in: Synovial sarcomas, fibrosarcomas, peritoneal leiomyomatosis, esophageal squamous cell and gastric adenocarcinomas. (?citation needed)
Reported positivity in uterine type retroperitoneal leiomyomas and leiomyomas colonized by Cajal cells. (?citation needed)
Practical Uses / PanelsEdit
Can be used in the gastrointestinal stromal tumor panel along with SMA, S100, CD34 and CD117
May be more sensitive in identifying gastrointestinal stromal tumors that are KIT-negative, have PDGFRA mutations or epithelioid morphologies.
West RB et al. The Novel Marker, DOG1, Is Expressed Ubiquitously in Gastrointestinal Stromal Tumors Irrespective of KIT or PDGFRA Mutation Status. Am J Pathol. 2004 July; 165(1): 107–113.
Espinosa I et al. A novel monoclonal antibody against DOG1 is a sensitive and specific marker for gastrointestinal stromal tumors. Am J Surg Pathol. 2008 Feb;32(2):210-8.
Miettinen M et al. DOG1 antibody in the differential diagnosis of gastrointestinal stromal tumors: a study of 1840 cases. Am J Surg Pathol. 2009 Sep;33(9):1401-8.
Lee CH et al. The utility of discovered on gastrointestinal stromal tumor 1 (DOG1) antibody in surgical pathology-the GIST of it. Adv Anat Pathol. 2010 May;17(3):222-32.
Yang YD et al. TMEM16A confers receptor-activated calcium-dependent chloride conductance. Nature 455, 1210-1215 (30 October 2008)