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  • EMA expression with membranous staining pattern in Malignant Extra-Renal Rhabdoid Tumor (MERT).
  • EMA expression in apocrine metaplasia of the breast. Note the prominent staining on the apical membrane of the cells.
  • EMA expression in apocrine metaplasia of the breast.
  • EMA expression in a cutaneous meningioma.
  • EMA expression in a cutaneous meningioma.
  • EMA expression in distal convoluted renal tubules.
  • EMA expression in a myoepithelioma.
  • EMA expression in plasma cells.
  • EMA expression in plasma cells.
  • EMA expression in plasma cells.
  • EMA expression in plasma cells.
  • EMA expression in a normal sebaceous gland. The epidermis is negative.
  • EMA expression in eccrine glands. Note that the nerve in the center also shows staining of the perineurium.


SynonymsEdit

AntibodiesEdit


Technical InfoEdit

Staining PatternEdit

Expression in Normal TissuesEdit

  • nearly all apical surfaces of ductular and glandular epithelium
  • normal plasma cells are often EMA positive
  • renal distal convoluted tubules[1]
  • renal collecting ducts[1]
  • perineural cells

Expression in Neoplastic EntitiesEdit

BenignEdit
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments
Meningioma 100%[2] 22[2]
Perineurioma


Intermediate/Uncertain Malignant PotentialEdit
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments


MalignantEdit
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments
Epithelioid sarcoma 85%[3] 20[3]
Synovial Sarcoma 91%[4] 23[4]
Low Grade Fibromyxoid Sarcoma

Expression in Non-Neoplastic EntitiesEdit

Pertinent NegativesEdit

The antigen is typically NOT expressed in the following:

Practical Uses / PanelsEdit

  • EMA may be useful if pancytokeratin is negative in a suspected synovial sarcoma, as it is more sensitive than cytokeratin in this setting.[5]

Common PitfallsEdit

ReferencesEdit

  1. 1.0 1.1 1.2 1.3 1.4 1.5 Modern Pathology (2004) 17, 180–188.
  2. 2.0 2.1 2.2 Am J Surg Pathol. 1986 Sep;10(9):640-9.
  3. 3.0 3.1 Mod Pathol 2001;14(7):655–663
  4. 4.0 4.1 Modern Pathology (2006) 19, 659–668
  5. Am J Surg Pathol. 2002 Nov;26(11):1434-40.

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