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  • Positive nuclear staining for estrogen receptor (ER) in ductal carcinoma of the breast.
  • ER expression in ovarian-like stroma cells in a rare example of angiomyolipoma with epithelial cyst.
  • ER expression in ovarian-like stroma cells and myoid tumor cells in a rare example of angiomyolipoma with epithelial cyst.
  • ER expression in myoid tumor cells in a rare example of angiomyolipoma with epithelial cyst.


SynonymsEdit

AntibodiesEdit

Technical InfoEdit

Staining PatternEdit

  • Nuclear (like all steroid receptors)

Expression in Normal TissuesEdit

  • Breast ductal and lobular epithelium

Expression in Neoplastic EntitiesEdit

BenignEdit
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments


Intermediate/Uncertain Malignant PotentialEdit
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments


MalignantEdit
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments
Breast carcinoma (variable)
Endometrial adenocarcinoma
Ovarian serous, mucinous, and endometrioid adenocarcinoma[1]
Urothelial carcinoma [2] 20%[2]
Ovarian transitional cell carcinoma[2]
Endometrial stromal sarcoma

Expression in Non-Neoplastic EntitiesEdit

Pertinent NegativesEdit

This antigen is typically NOT expressed by the following entities:

  • Endocervical adenocarcinoma
  • Ovarian clear cell carcinoma[1]

Practical Uses / PanelsEdit

  • Predictive marker in breast carcinoma (tamoxifen response and survival)[3]
  • Endocervical (ER-) vs. endometrial carcinomas (ER +)[4]

Common PitfallsEdit

Related Links/Other ResourcesEdit

ReferencesEdit

  1. 1.0 1.1 Fujimura M, Hidaka T, Kataoka K, Yamakawa Y, Akada S, Teranishi A, Saito S. Absence of estrogen receptor-alpha in human ovarian clear cell adenocarcinoma compared with ovarian serous, endometrioid, and mucinous adenocarcinoma. Am J Surg Pathol.2001;15(5):667-72
  2. 2.0 2.1 2.2 Croft PR, Lathrop SL, Feddersen RM, Joste NE. Estrogen receptor expressionin papillary urothelial carcinoma of the bladder and ovarian transitional cell carcinoma. Arch Pathol Lab Med. 2005;125(2):194-9
  3. Hammond ME, Hayes DF, Dowsett M, Allred DC, Hagerty KL, Badve S, Fitzgibbons PL, Francis G, Goldstein NS, Hayes M, Hicks DG, Lester S, Love R, Mangu PB, McShane L, Miller K, Osborne CK, Paik S, Perlmutter J, Rhodes A, Sasano H, Schwartz JN, Sweep FC, Taube S, Torlakovic EE, Valenstein P, Viale G, Visscher D, Wheeler T, Williams RB, Wittliff JL, Wolff AC. American Society of Clinical Oncology/College of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer. Arch Pathol Lab Med. 2010;134(7):e48-72
  4. Stabler A, Sherman ME, Zaino RJ, Ronnett BM. Hormone receptor immunohistochemistry and human papillomavirus in situ hybridization are useful for distinguishing endocervical and endometrial adenocarcinomas. Am J Surg Pathol. 2002;26(8):998-1006

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