Synonyms[]
Antibodies[]
Technical Info[]
Staining Pattern[]
- Nuclear (like all steroid receptors)
Expression in Normal Tissues[]
- Breast ductal and lobular epithelium
Expression in Neoplastic Entities[]
Benign[]
| Tumor name | % Positive Staining (Sensitivity) | Number of Cases | Specificity | Comments |
Intermediate/Uncertain Malignant Potential[]
| Tumor name | % Positive Staining (Sensitivity) | Number of Cases | Specificity | Comments |
Malignant[]
| Tumor name | % Positive Staining (Sensitivity) | Number of Cases | Specificity | Comments |
| Breast carcinoma (variable) | ||||
| Endometrial adenocarcinoma | ||||
| Ovarian serous, mucinous, and endometrioid adenocarcinoma[1] | ||||
| Urothelial carcinoma [2] | 20%[2] | |||
| Ovarian transitional cell carcinoma[2] | ||||
| Endometrial stromal sarcoma | ||||
Expression in Non-Neoplastic Entities[]
Pertinent Negatives[]
This antigen is typically NOT expressed by the following entities:
- Endocervical adenocarcinoma
- Ovarian clear cell carcinoma[1]
Practical Uses / Panels[]
- Predictive marker in breast carcinoma (tamoxifen response and survival)[3]
- Endocervical (ER-) vs. endometrial carcinomas (ER +)[4]
Common Pitfalls[]
Related Links/Other Resources[]
References[]
- ↑ 1.0 1.1 Fujimura M, Hidaka T, Kataoka K, Yamakawa Y, Akada S, Teranishi A, Saito S. Absence of estrogen receptor-alpha in human ovarian clear cell adenocarcinoma compared with ovarian serous, endometrioid, and mucinous adenocarcinoma. Am J Surg Pathol.2001;15(5):667-72
- ↑ 2.0 2.1 2.2 Croft PR, Lathrop SL, Feddersen RM, Joste NE. Estrogen receptor expressionin papillary urothelial carcinoma of the bladder and ovarian transitional cell carcinoma. Arch Pathol Lab Med. 2005;125(2):194-9
- ↑ Hammond ME, Hayes DF, Dowsett M, Allred DC, Hagerty KL, Badve S, Fitzgibbons PL, Francis G, Goldstein NS, Hayes M, Hicks DG, Lester S, Love R, Mangu PB, McShane L, Miller K, Osborne CK, Paik S, Perlmutter J, Rhodes A, Sasano H, Schwartz JN, Sweep FC, Taube S, Torlakovic EE, Valenstein P, Viale G, Visscher D, Wheeler T, Williams RB, Wittliff JL, Wolff AC. American Society of Clinical Oncology/College of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer. Arch Pathol Lab Med. 2010;134(7):e48-72
- ↑ Stabler A, Sherman ME, Zaino RJ, Ronnett BM. Hormone receptor immunohistochemistry and human papillomavirus in situ hybridization are useful for distinguishing endocervical and endometrial adenocarcinomas. Am J Surg Pathol. 2002;26(8):998-1006