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Factor VIII Related Antigen (von Willebrand Factor)

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  • Factor VIII-associated antigen expression in epithelioid hemagioendothelioma of the liver.
  • Factor VIII-associated antigen expression in epithelioid hemagioendothelioma of the liver.
  • Factor VIII-associated antigen expression in epithelioid hemagioendothelioma of the liver.

SynonymsEdit

  • Factor VIII (FVIII) (Factor 8) - This is technically not correct. The stain is actually for von Willebrand Factor, also known as Factor VIII related antigen.
  • FVIII
  • von Willebrand Factor (vWF)

AntibodiesEdit

Technical InfoEdit

Staining PatternEdit

  • Cytoplasmic

Expression in Normal TissuesEdit

  • Vascular endothelium (Weibel-Palade bodies in endothelial cells store vWF)

Expression in Neoplastic EntitiesEdit

BenignEdit
  • Hemangioma


IntermediateEdit
  • Epithelioid Hemangioendothelioma
MalignantEdit
  • Angiosarcoma

Expression in Non-Neoplastic EntitiesEdit

Pertinent NegativesEdit

This antigen is typically NOT expressed by the following entities:

Practical Uses / PanelsEdit

Common PitfallsEdit

  • Because vWF is also present in serum, this immunostain can have high background staining. CD31 and CD34 are probably better immunostains for endothelium in that respect.

Related Links/Other ResourcesEdit

ReferencesEdit

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