Synonyms[]
Antibodies[]
Technical Info[]
Staining Pattern[]
- Cytoplasmic
Expression in Normal Tissues[]
- Histiocytes
- Fibrohistiocytes
Expression in Neoplastic Entities[]
Benign[]
Benign[]
| Tumor name | % Positive Staining (Sensitivity) | Number of Cases | Specificity | Comments | |
| Benign Fibrous Histiocytoma (dermatofibroma) | 100%[1] | 56/56[1] | |||
Intermediate/Uncertain Malignant Potential[]
| Tumor name | % Positive Staining (Sensitivity) | Number of Cases | Specificity | Comments |
Malignant[]
| Tumor name | % Positive Staining (Sensitivity) | Number of Cases | Specificity | Comments |
Expression in Non-Neoplastic Entities[]
Practical Uses / Panels[]
- Factor XIIIa can be used in a panel with D2-40 and CD34 to differentiate between DFSP (factor XIIIa-, D2-40-, CD34+) and dermatofibroma (factor XIIIa+, D2-40+, CD34-).[1] However, exceptions occur.
- Factor XIIIa is a pan-histiocytic marker, similar to CD68.
Common Pitfalls[]
- Not specific for dermatofibroma.