Synonyms[]
KOC, L523S
Antibodies[]
Technical Info[]
Staining Pattern[]
Cytoplasmic
Expression in Normal Tissues[]
- Expressed during embryogenesis with greatest expression in gut, pancreas, kidney, and brain; Limited expression in adults, to mainly placental intermediate trophoblasts, with also limited expression in LN germinal centers, ovary, testis, brain, internal root sheath of hair follicles and intestinal and endocervical mucosa [1]
Expression in Neoplastic Entities[]
Benign[]
| Tumor name | % Positive Staining (Sensitivity) | Number of Cases | Specificity | Comments |
Intermediate/Uncertain Malignant Potential[]
| Tumor name | % Positive Staining (Sensitivity) | Number of Cases | Specificity | Comments |
Malignant[]
| Tumor name | % Positive Staining (Sensitivity) | Number of Cases | Specificity | Comments |
| Uterine serous carcinoma[2] | ||||
Additional Comments:[]
Expression in Non-Neoplastic Entities[]
Pertinent Negatives[]
This antigen is typically NOT expressed by the following entities:
- Endometrioid adenocarcinoma of the uterus.[2]
Practical Uses / Panels[]
- Can be used to stratify atypical carcinoids of the lung associated with higher mortality and recurrence risk.[3]