Nuclear MUM1 positive plasma cell in a patient with Plasma cell Myeloma
Synonyms[]
- MUM1 (Multiple myeloma oncogene-1)
- IRF4 (Interferon regulatory factor 4)
Antibodies[]
Technical Info[]
Staining Pattern[]
- Nuclear (like all transcription factors)
Expression in Normal Tissues[]
- Melanocytes
- Germinal center B-cells from the light zone (not the dark zone)
Expression in Neoplastic Entities[]
Benign[]
| Tumor name | % Positive Staining | Number of Cases |
Intermediate/Uncertain Malignant Potential[]
| Tumor name | % Positive Staining | Number of Cases |
Malignant[]
| Tumor name | % Positive Staining | Number of Cases |
Malignant[]
- Multiple myeloma
- Activated (non-germinal center) type of diffuse large B-cell lymphoma (DLBCL)[1]
- Reed-Sternberg / Hodgkin cells
- Melanoma (some)[2]
Expression in Non-Neoplastic Entities[]
Pertinent Negatives[]
This antigen is typically NOT expressed by the following entities: