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Synonyms[]

SRY-related HMG-box

Antibodies[]

clone 20B7

Technical Info[]

Staining Pattern[]

Nuclear and cytoplasmic

Expression in Normal Tissues[]

This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. In the central nervous system, SOX10 is required for the terminal differentiation of oligodendrocytes and myelination. In the peripheral nervous system, SOX10 maintains pluripotency of neural crest stem cells and suppresses neuronal differentiation.

  • Schwann cells[1]
  • Melanocytes[1]
  • Myoepithelial cells[1]

Expression in Neoplastic Entities[]

  • Clear cell sarcoma of tendons and aponeuroses
  • Gastrointestinal Neuroectodermal Tumor (GNET)
Benign[]
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments
Neurofibroma[1]
Schwannoma[1]
Myoepithelioma[1]
Capsular nevi in lymph nodes[1]
Sustentacular cells only of paraganglioma/pheochromocytoma (tumor cells negative)[1]


Intermediate/Uncertain Malignant Potential[]
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments
Carcinoid tumors (occasionally)[1]


Malignant[]
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments
Desmoplastic melanoma 100%[2] 9/9[2]
Melanoma in-situ 100%[2] 14/14[2]
GNET 100% 15/15
Clear cell sarcoma 100%
Diffuse astrocytoma[1]
Melanoma 97%[1] 76/78[1]
Malignant peripheral nerve sheath tumor (MPNST) 49%[1] 38/77[1]
Metastatic melanoma in lymph nodes[1]
Additional Comments:[]

Expression in Non-Neoplastic Entities[]

Pertinent Negatives[]

This antigen is typically NOT expressed by the following entities:

  • Dendritic cells in lymph nodes [1]

Practical Uses / Panels[]

  • For desmoplastic melanoma, SOX10 is more sensitive than MiTF and more specific than S100 Protein (i.e. - less likely to stain background fibroblasts and histiocytes).[2]

Common Pitfalls[]

Related Links/Other Resources[]

References[]

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