Synonyms[]
SRY-related HMG-box
Antibodies[]
clone 20B7
Technical Info[]
Staining Pattern[]
Nuclear and cytoplasmic
Expression in Normal Tissues[]
This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. In the central nervous system, SOX10 is required for the terminal differentiation of oligodendrocytes and myelination. In the peripheral nervous system, SOX10 maintains pluripotency of neural crest stem cells and suppresses neuronal differentiation.
Expression in Neoplastic Entities[]
- Clear cell sarcoma of tendons and aponeuroses
- Gastrointestinal Neuroectodermal Tumor (GNET)
Benign[]
Tumor name | % Positive Staining (Sensitivity) | Number of Cases | Specificity | Comments |
Neurofibroma[1] | ||||
Schwannoma[1] | ||||
Myoepithelioma[1] | ||||
Capsular nevi in lymph nodes[1] | ||||
Sustentacular cells only of paraganglioma/pheochromocytoma (tumor cells negative)[1] | ||||
Intermediate/Uncertain Malignant Potential[]
Tumor name | % Positive Staining (Sensitivity) | Number of Cases | Specificity | Comments |
Carcinoid tumors | (occasionally)[1] | |||
Malignant[]
Tumor name | % Positive Staining (Sensitivity) | Number of Cases | Specificity | Comments |
Desmoplastic melanoma | 100%[2] | 9/9[2] | ||
Melanoma in-situ | 100%[2] | 14/14[2] | ||
GNET | 100% | 15/15 | ||
Clear cell sarcoma | 100% | |||
Diffuse astrocytoma[1] | ||||
Melanoma | 97%[1] | 76/78[1] | ||
Malignant peripheral nerve sheath tumor (MPNST) | 49%[1] | 38/77[1] | ||
Metastatic melanoma in lymph nodes[1] | ||||
Additional Comments:[]
Expression in Non-Neoplastic Entities[]
Pertinent Negatives[]
This antigen is typically NOT expressed by the following entities:
- Dendritic cells in lymph nodes [1]
Practical Uses / Panels[]
- For desmoplastic melanoma, SOX10 is more sensitive than MiTF and more specific than S100 Protein (i.e. - less likely to stain background fibroblasts and histiocytes).[2]
Common Pitfalls[]
Related Links/Other Resources[]
References[]
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 1.14 1.15 Am J Surg Pathol. 2008 Sep;32(9):1291-8.
- ↑ 2.0 2.1 2.2 2.3 2.4 Ramos-Herberth FI, Karamchandani J, Kim J, Dadras SS. SOX10 immunostaining distinguishes desmoplastic melanoma from excision scar. J Cutan Pathol. 2010 Sep;37(9):944-52.