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  • GLUT-1 expression in trophoblasts and endothelium in normal placenta.
  • GLUT-1 expression in trophoblasts and endothelium in normal placenta.
  • GLUT-1 expression in intravascular erythrocytes.

SynonymsEdit

  • Glucose transporter 1
  • GLUT-1

AntibodiesEdit

Technical InfoEdit

Staining PatternEdit

  • Membranous

Expression in Normal TissuesEdit

  • Perineurium[1]
  • Red blood cells (erythrocytes)[2]
  • Germinal cells of the testis[2]
  • Renal tubules[2]
  • Endothelial cells in blood–brain barrier vessels[2]
  • Placenta (trophoblasts and capillaries)[2]

Expression in Neoplastic EntitiesEdit

BenignEdit
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments
*Perineurioma[1] 100%[3] 3/3[3]


Intermediate/Uncertain Malignant PotentialEdit
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments


MalignantEdit
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments
Malignant mesothelioma 100%[2] 48/48[2]
Squamous cell carcinoma (pulmonary) 100%[2] 28/28[2]
Pulmonary adenocarcinoma 93.5%[2] 28/30[2]
Ovarian carcinoma 100%[4] 78/78[4]

Expression in Non-Neoplastic EntitiesEdit

Pertinent NegativesEdit

This antigen is typically NOT expressed by the following entities:

  • Reactive mesothelium (NEGATIVE in 100% [40/40 cases])
  • Benign ovarian tumors [4]
  • Low-grade fibromyxoid sarcoma

Practical Uses / PanelsEdit

  • GLUT-1 can be used to distinguish perineurioma (usually GLUT-1 +) from low-grade fibromyxoid sarcoma (usually GLUT-1 -).
  • GLUT-1 can be used to distinguish between mesothelioma (usually GLUT-1 +) from reactive mesothelium (usually GLUT-1 -).[2]

Common PitfallsEdit

  • GLUT-1 cannot be used to differentiate pulmonary carcinoma from mesothelioma as both are GLUT-1 +.[2]

Related Links/Other ResourcesEdit

ReferencesEdit

  1. 1.0 1.1 Mod Pathol 2003;16(4):293–298
  2. 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 2.12 Modern Pathology (2007) 20, 215–220.
  3. 3.0 3.1 Human Pathology (2008) 39, 1519–1526
  4. 4.0 4.1 4.2 Rudlowski C, Moser M, Becker AJ, Rath W, Buttner R, Schroder W, Schurmann A. GLUT1 mRNA and protein expression ini ovarian borderline tumors and cancer. Oncology. 2004;66(5):404-10

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