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SynonymsEdit

AntibodiesEdit

Technical InfoEdit

Staining PatternEdit

Nuclear or cytoplasmic staining pattern

Expression in Normal TissuesEdit

Expression in Neoplastic EntitiesEdit

BenignEdit
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments
Parathyroid Adenoma 3.3% 30


Intermediate/Uncertain Malignant PotentialEdit
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments


MalignantEdit
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments
Parathyroid Carcinoma 96%[1] 26[1] 90%[1]
Papillary Thyroid Carcinoma 72.6%[2] 84[2] Not sensitive or specific for thyroid carcinoma when used alone.
Additional Comments:Edit

Expression in Non-Neoplastic EntitiesEdit

Pertinent NegativesEdit

This antigen is typically NOT expressed by the following entities:

Practical Uses / PanelsEdit

In the context of the thyroid:

  • Coexpression with HBME-1 or Fibronectin-1 is restricted to carcinomas but not very sensitive.[3]
  • Concurrent absence with HBME-1 or Fibronectin-1 is highly specific for benign lesions.[3]

Common PitfallsEdit

Cannot be used to differentiate Papillary Thyroid Carcinoma from Hashimoto's Thyroiditis, especially the fibrous variant since the latter can intensely react with Galectin-3. This holds true even when used with HBME-1 or Fibronectin-1.[4]

Related Links/Other ResourcesEdit

ReferencesEdit

  1. 1.0 1.1 1.2 Hum Pathol. 2005 Aug;36(8):908-14.
  2. 2.0 2.1 Histopathology. 2005 Oct;47(4):391-401.
  3. 3.0 3.1 Mod Pathol. 2005 Jan;18(1):48-57.
  4. Histopathology. 2006 Aug;49(2):107-20.

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