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Gross Cystic Disease Fluid Protein 15 (GCDFP-15, BRST-2)

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  • BRST-2 expression in high grade breast carcinoma.
  • BRST-2 expression in ductal carcinoma of breast.

SynonymsEdit

  • GCDFP-15
  • BRST-2

AntibodiesEdit

Technical InfoEdit

Staining PatternEdit

  • Cytoplasmic

Expression in Normal TissuesEdit

  • apocrine sweat glands[1]
  • eccrine glands (variable)[1]
  • minor salivary glands[1]
  • bronchial glands[1]
  • metaplastic epithelium of the breast[1]
  • serous cells of the submandibular gland[1]

Expression in Neoplastic EntitiesEdit

BenignEdit
Tumor name % Positive Staining Number of Cases
benign sweat gland tumors of the skin [1]


Intermediate/Uncertain Malignant PotentialEdit
Tumor name % Positive Staining Number of Cases


MalignantEdit
Tumor name % Positive Staining Number of Cases
Breast carcinomas (primary and metastatic lesions) with apocrine features[1]
extramammary Paget's Disease[1]

Expression in Non-Neoplastic EntitiesEdit

Pertinent NegativesEdit

This antigen is typically NOT expressed by the following entities:

Practical Uses / PanelsEdit

Common PitfallsEdit

Related Links/Other ResourcesEdit

ReferencesEdit

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 [1]

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