• IMP3 staining in metastatic small cell carcinoma of the lung to a medistinal LM (400x).Go to
  • IMP3 staining in poorly differentiated lung adenocarcinoma (400x).Go to


KOC, L523S


Technical InfoEdit

Staining PatternEdit


Expression in Normal TissuesEdit

  • Expressed during embryogenesis with greatest expression in gut, pancreas, kidney, and brain; Limited expression in adults, to mainly placental intermediate trophoblasts, with also limited expression in LN germinal centers, ovary, testis, brain, internal root sheath of hair follicles and intestinal and endocervical mucosa [1]

Expression in Neoplastic EntitiesEdit

Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments

Intermediate/Uncertain Malignant PotentialEdit
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments

Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments
Uterine serous carcinoma[2]
Additional Comments:Edit

Expression in Non-Neoplastic EntitiesEdit

Pertinent NegativesEdit

This antigen is typically NOT expressed by the following entities:

  • Endometrioid adenocarcinoma of the uterus.[2]

Practical Uses / PanelsEdit

  • Can be used to stratify atypical carcinoids of the lung associated with higher mortality and recurrence risk.[3]

Common PitfallsEdit

Related Links/Other ResourcesEdit


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  2. 2.0 2.1 [1]
  3. Del Gobbo  A, Vaira V, Guerini Rocco E, et al. The oncofetal protein IMP3: a useful marker to predict poor clinical outcome in neuroendocrine tumors of the lung.  J Thorac Oncol 2014;9: 1656-61.

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