• Nuclear MDM2 expression in dedifferentiated liposarcoma.


  • Murine Double Minute 2 (MDM2)


Technical InfoEdit

Staining PatternEdit

  • Nuclear

Expression in Normal TissuesEdit

Expression in Neoplastic EntitiesEdit

Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments

Intermediate/Uncertain Malignant PotentialEdit
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments

Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments
Atypical lipomatous neoplasm (tumor) / Well differentiated liposarcoma 100%[1] 59%[1]
Dedifferentiated Liposarcoma
Parosteal osteosarcoma[2]

Expression in Non-Neoplastic EntitiesEdit

Pertinent NegativesEdit

This antigen is typically NOT expressed by the following entities:

  • Benign lipomatous tumors [1]

Practical Uses / PanelsEdit

  • MDM2 can be used with CDK4 to differentiate malignant lipomatous tumors (i.e. liposarcoma; positive for both stains) from benign lipomatous tumors (i.e. lipomas; weak or negative for both stains). 

Common PitfallsEdit

  • MDM2 can be incorrectly interpreted as positive with weak, patchy positivity; greater than 30% strong tumor staining should be interpreted as positive.[1]

Related Links/Other ResourcesEdit


  1. 1.0 1.1 1.2 1.3 Aleixo PB, Hartmann AA, Menezes IC, Meurer RT, Oliveira AM. Can MDM2 and CDK4 make the diagnosis of well differentiated/dedifferentiated liposarcoma? An immunohistochemical study on 129 soft tissue tumours. J Clin Pathol. 2009 Dec;62(12):1127-35.
  2. Takashi Tsuchiyaa, Ki-ichi Sekineb, Shin-ichi Hinoharab, Takeshi Namikia, c, Tsutomu Noboria, c and Yasuhiko Kaneko. Analysis of the p16INK4, p14ARF, p15, TP53, and MDM2 Genes and Their Prognostic Implications in Osteosarcoma and Ewing Sarcoma. Cancer Genetics and Cytogenetics. Volume 120, Issue 2, 15 July 2000, Pages 91-98.

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