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Microphthalmia-associated transcription factor (MiTF)

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  • MiTF expression in metastatic melanoma.
  • MiTF expression in metastatic melanoma.
  • Nuclear MiTF expression in a cellular neurothekeoma.
  • Nuclear MiTF expression in a cellular neurothekeoma.

SynonymsEdit

  • Microphthalmia-associated transcription factor
  • MiTF

AntibodiesEdit

Technical InfoEdit

Staining PatternEdit

  • Nuclear

Expression in Normal TissuesEdit

  • Melanocytes
  • Histiocytes[1]

Expression in Neoplastic EntitiesEdit

BenignEdit
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments
Neurothekeoma
Cellular Neurothekeoma
Melanocytic nevus


Intermediate/Uncertain Malignant PotentialEdit
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments


MalignantEdit
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments
Melanoma
Clear Cell Sarcoma 81%[2] 26/32[2]

Expression in Non-Neoplastic EntitiesEdit

Pertinent NegativesEdit

This antigen is typically NOT expressed by the following entities:

Practical Uses / PanelsEdit

Common PitfallsEdit

Related Links/Other ResourcesEdit

ReferencesEdit

  1. Am J Surg Pathol. 2001 Feb;25(2):205-11.
  2. 2.0 2.1 Am J Surg Pathol. 2008 Mar;32(3):452-60.

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