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  • Myogenin expression in skeletal muscle nuclei. Intervening tumor nuclei are negative.
  • Myogenin expression in skeletal muscle nuclei. Intervening tumor nuclei are negative.
  • Myogenin expression in skeletal muscle entrapped by tumor. The nuclei run parallel to one another, a clue that they are entrapped muscle rather than tumor.
  • Myogenin expression in mast cells. Tumor cells are negative.
  • Myogenin expression in mast cells. Tumor cells are negative.
  • Myogenin expression in mast cells. Tumor cells are negative.
  • Myogenin expression in mast cells. Tumor cells are negative.
  • Myogenin expression in mast cells. Tumor cells are negative.
  • Myogenin expression in mast cells. Tumor cells are negative.
Nuclear regulatory factor that plays an important role in skeletal muscle differentiation. It is expressed by rhabdomyosarcomas.

SynonymsEdit

  • myf4

AntibodiesEdit

Technical InfoEdit

Staining PatternEdit

  • Nuclear

Expression in Normal TissuesEdit

Expression in Neoplastic EntitiesEdit

BenignEdit
MalignantEdit
  • Rhabdomyosarcoma

Expression in Non-Neoplastic EntitiesEdit

Practical Uses / PanelsEdit

Common PitfallsEdit

  • Sclerosing rhabdomyosarcoma is often only focally and weakly positive for myogenin, although myoD1 is usually strongly and diffusely positive. [1]
  • Mast cells often artifactually stain for myogenin, mimicking positive nuclei on low power.

ReferencesEdit

  1. Am J Surg Pathol. 2002 Sep;26(9):1175-83.

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