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  • p16 expression is a surrogate marker for HPV infection in this oral squamous cell carcinoma.
  • p16 expression is a surrogate marker for HPV infection in this oral squamous cell carcinoma.

SynonymsEdit

MTS1, CDKN2A

AntibodiesEdit

Technical InfoEdit

Staining PatternEdit

  • Nuclear and cytoplasmic

Expression in Normal TissuesEdit

Expression in Neoplastic EntitiesEdit

BenignEdit
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments


MalignantEdit
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments
HPV-associated squamous cell carcinoma of head and neck
HPV-associated squamous cell carcinoma of cervix[1]

Expression in Non-Neoplastic EntitiesEdit

Pertinent NegativesEdit

This antigen is typically NOT expressed by the following entities:

  • Reactive or atypical squamous epithelium of cervix [1]

Practical Uses / PanelsEdit

  • In the cervix, p16 can be used with Ki-67 (MIB-1) to differentiate between atrophy or reactive squamous epithelium (p16 focally + or negative, Ki-67 restricted to basal layer) from high-grade dysplasia (diffuse p16 +, Ki-67 diffuse +).[1] [2]
  • In the gynecological tract, p16 can be used (similar to p53) to distinguish serous carcinoma (strong and diffuse p16+ and p53+) from endometrioid adenocarcinoma (patchy and weak p16 and p53).

Common PitfallsEdit

  • In cervix, interpretation of Ki-67 may be difficult due to tangential sectioning or loss of the outer layer of epithelium because it is expressed in the parabasal cells.

Related Links/Other ResourcesEdit

ReferencesEdit

  1. 1.0 1.1 1.2 [1] Mod Pathol. 2003 Jul;16(7):665-73. 
  2. Am J Surg Pathol. 2002 Nov;26(11):1501-7.

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