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P40

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SynonymsEdit

AntibodiesEdit

Technical InfoEdit

Staining PatternEdit

Expression in Normal TissuesEdit

Expression in Neoplastic EntitiesEdit

BenignEdit
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments


Intermediate/Uncertain Malignant PotentialEdit
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments


MalignantEdit
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments
Squamous cell carcinoma[1] 98%[1]
Additional Comments:Edit

Expression in Non-Neoplastic EntitiesEdit

Pertinent NegativesEdit

This antigen is typically NOT expressed by the following entities:

  • Adenocarcinoma

Practical Uses / PanelsEdit

  • p40 has similar sensitivity to p63 for squamous cell carcinoma but has much greater specificity than p63. p40 is more very helpful in differentiating squamous cell carcinoma from adenocarcinoma of the lung than p63.[1]

Common PitfallsEdit

Related Links/Other ResourcesEdit

ReferencesEdit

  1. 1.0 1.1 1.2 Mod Pathol. 2012 Mar;25(3):405-15.

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