Technical InfoEdit

Staining PatternEdit

  • Nuclear

Expression in Normal TissuesEdit

  • p53 is not generally expressed at high levels in normal cells.

Expression in Neoplastic EntitiesEdit


  • High grade serous carcinoma[1]

Expression in Non-Neoplastic EntitiesEdit

Pertinent NegativesEdit

This antigen is typically NOT expressed by the following entities:

  • Endometrioid adenocarcinoma[2]

Practical Uses / PanelsEdit

  • p53 can be used to distinguish urothelial flat carcinoma in situ (p53+) from reactive urothelium (p53-).
  • p53 can be used with IMP3 and PTEN to distinguish gynecologic serous carcinoma (diffuse and strongly p53+ IMP3+, PTEN+) from endometrioid carcinoma (p53- or focally +, IMP3-, PTEN-).[2]

Common PitfallsEdit

Related Links/Other ResourcesEdit


  1. O'Neill CJ, Deavers MT, Malpica A, Foster H, McCluggage WG. Am J Surg Pathol. 2005 Aug;29(8):1034-41
  2. 2.0 2.1 [ Mhawech-Fauceglia P, Herrmann FR, Rai H, Tchabo N, Lele S, Izevbaye I, Odunsi K, Cheney RT. IMP3 distinguishes uterine serous carcinoma from endometrial endometrioid adenocarcinoma. Am J Clin Pathol. 2010 Jun;133(6):899-908.]

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