Fandom

Pathology Resident Wiki

P53

557pages on
this wiki
Add New Page
Talk0 Share

SynonymsEdit

AntibodiesEdit

Technical InfoEdit

Staining PatternEdit

  • Nuclear

Expression in Normal TissuesEdit

  • p53 is not generally expressed at high levels in normal cells.

Expression in Neoplastic EntitiesEdit

BenignEdit


IntermediateEdit
MalignantEdit
  • High grade serous carcinoma[1]

Expression in Non-Neoplastic EntitiesEdit

Pertinent NegativesEdit

This antigen is typically NOT expressed by the following entities:

  • Endometrioid adenocarcinoma[2]

Practical Uses / PanelsEdit

  • p53 can be used to distinguish urothelial flat carcinoma in situ (p53+) from reactive urothelium (p53-).
  • p53 can be used with IMP3 and PTEN to distinguish gynecologic serous carcinoma (diffuse and strongly p53+ IMP3+, PTEN+) from endometrioid carcinoma (p53- or focally +, IMP3-, PTEN-).[2]

Common PitfallsEdit

Related Links/Other ResourcesEdit

ReferencesEdit

  1. O'Neill CJ, Deavers MT, Malpica A, Foster H, McCluggage WG. Am J Surg Pathol. 2005 Aug;29(8):1034-41
  2. 2.0 2.1 [http://www.ncbi.nlm.nih.gov/pubmed/20472848 Mhawech-Fauceglia P, Herrmann FR, Rai H, Tchabo N, Lele S, Izevbaye I, Odunsi K, Cheney RT. IMP3 distinguishes uterine serous carcinoma from endometrial endometrioid adenocarcinoma. Am J Clin Pathol. 2010 Jun;133(6):899-908.]

Ad blocker interference detected!


Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers

Wikia is not accessible if you’ve made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected.