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  • p57KIP2


Technical InfoEdit

Staining PatternEdit

  • Nuclear

Expression in Normal TissuesEdit

  • Villous stroma[1]
  • Villous cytotrophoblasts[1]

Expression in Neoplastic EntitiesEdit

LOSS of p57 nuclear staining is seen in the following:

Tumor name % Positive Staining Number of Cases
Intermediate/Uncertain Malignant PotentialEdit
Tumor name % Positive Staining Number of Cases
Tumor name % Positive Staining Number of Cases
Complete Mole 98%[1] 58/59 [1]

Expression in Non-Neoplastic EntitiesEdit

Pertinent NegativesEdit

INTACT p57 nuclear staining is seen in the following:

  • Partial mole[1]
  • Hydropic abortus[1]

Practical Uses / PanelsEdit

  • p57 is useful in the differential diagnosis of hydatidiform moles. p57 expression is intact in partial mole and hydropic abortus but is lost in compete mole.

Common PitfallsEdit

  • A significant p57 stain result will show LOSS of nuclear p57 staining in the villous stroma and villous cytotrophoblasts. To interpret this stain and ensure that it worked correctly, you MUST see nuclear staining on decidua and intermediate trophoblasts (which serve as an internal control).
  • Partial mole and hydropic abortus have intact p57 expression in the villous stroma and cytotrophoblasts.

Related Links/Other ResourcesEdit


  1. 1.0 1.1 1.2 1.3 1.4 1.5 Discrimination of complete hydatidiform mole from its mimics by immunohistochemistry of the paternally imprinted gene product p57KIP2. Am J Surg Pathol. 2001 Oct;25(10):1225-30.

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