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SynonymsEdit

  • NGFR
  • Neurotrophin receptor
  • p75

AntibodiesEdit

Technical InfoEdit

Staining PatternEdit

Expression in Normal TissuesEdit

  • Breast myoepithelial cells[1]

Expression in Neoplastic EntitiesEdit

BenignEdit
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments
myxoid/hypocellular neurothekeoma (nerve sheath myxoma) 100%[2] 10/10[2]


Intermediate/Uncertain Malignant PotentialEdit
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments


MalignantEdit
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments

Pertinent NegativesEdit

This antigen is typically NOT expressed in the following:

  • Cellular neurothekeoma[2]


Expression in Non-Neoplastic EntitiesEdit

Practical Uses / PanelsEdit

  • p75(NGFR) immunostaining for the detection of perineural invasion by cutaneous squamous cell carcinoma.[3]

Common PitfallsEdit

ReferencesEdit

  1. Modern Pathology (2005) 18, 1535–1541
  2. 2.0 2.1 2.2 Hum Pathol. 2000 Oct;31(10):1230-41.
  3. Dermatol Surg. 2006 Feb;32(2):177-83.

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