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  • PAX-2 expression in proximal tubules of kidney.

SynonymsEdit

AntibodiesEdit

Technical InfoEdit

Staining PatternEdit

Expression in Normal TissuesEdit

  • Proximal renal tubules
  • Epididymus epithelium[1]

Expression in Neoplastic EntitiesEdit

BenignEdit
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments
Nephrogenic Adenoma 100%[2] 39/39[2]
Clear cell papillary cystadenoma of the epididymis 100%[1] 1/1[1]


Intermediate/Uncertain Malignant PotentialEdit
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments


MalignantEdit
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments
Renal cell carcinoma 85%[1] 23/27[1]
Clear Cell Carcinoma of Ovary 43%[1] 3/7[1]
Parathyroid Carcinoma 33%[1] 1/3[1]
Additional Comments:Edit

Expression in Non-Neoplastic EntitiesEdit

Pertinent NegativesEdit

This antigen is typically NOT expressed by the following entities:

  • Prostatic adenocarcinoma[2]

Practical Uses / PanelsEdit

  • Can be used to differentiate Nephrogenic Adenoma (Pax2+) from Prostatic Adenocarcinoma (Pax2-)[2]

Common PitfallsEdit

Related Links/Other ResourcesEdit

ReferencesEdit

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Am J Surg Pathol. 2008 Oct;32(10):1462-7.
  2. 2.0 2.1 2.2 2.3 Mod Pathol. 2006 Mar;19(3):356-63.

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