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Phospho-Histone H3 (PHH3) immunostain highlights mitotic figures.

SynonymsEdit

  • Phospho-Histone H3
  • PHH3

AntibodiesEdit

Technical InfoEdit

Staining PatternEdit

  • Nuclear (Stained nuclei must have mitotic chromosomal arrangement. Normal interphase nuclei that stain should be ignored.)[1]

Expression in Normal TissuesEdit

Expression in Neoplastic EntitiesEdit

BenignEdit
IntermediateEdit
MalignantEdit

Expression in Non-Neoplastic EntitiesEdit

Practical Uses / PanelsEdit

  • MPM2 immunostain has been used to highlight the presence of mitoses in benign nevi.[1]

Common PitfallsEdit

ReferencesEdit

  1. 1.0 1.1 K Glatz, C Hartmann, M Antic, H Kutzner. Frequent Mitotic Activity in Banal Melanocytic Nevi Uncovered by Immunohistochemical Analysis. Am J Dermatopathol. Oct 2010. 32(7):643-649.

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