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Placental Alkaline Phosphatase (PLAP)

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  • PLAP expression in intratubular germ cell neoplasia (ICGNU) of testis.
  • PLAP staining syncytiotrophoblasts in normal placenta.
  • PLAP expression in seminoma.
  • PLAP expression in seminoma.
  • PLAP expression in seminoma.
  • PLAP expression in placenta trophoblasts.

SynonymsEdit

AntibodiesEdit

Technical InfoEdit

Staining PatternEdit

Expression in Normal TissuesEdit

  • Syncytiotrophoblasts

Expression in Neoplastic EntitiesEdit

BenignEdit
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments


Intermediate/Uncertain Malignant PotentialEdit
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments
Intratubular germ cell neoplasia, unclassified (IGCNU)


MalignantEdit
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments
Choriocarcinoma 45%[1] 203[1]
Embryonal Carcinoma 96%[1] 203[1]
Seminoma / Germinoma 96%[1] 203[1]
Yolk sac tumor 25%[1] 203[1]

Expression in Non-Neoplastic EntitiesEdit

Pertinent NegativesEdit

This antigen is typically NOT expressed by the following entities:

  • Normal testicular germ cells (spermatogonia)

Practical Uses / PanelsEdit

Common PitfallsEdit

Related Links/Other ResourcesEdit

ReferencesEdit

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Hum Pathol. 1988 Jun;19(6):663-70.

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