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  • PR staining in normal breast lobules.
  • PR positive ductal breast carcinoma.
  • PR expression in ovarian-like stroma cells in a rare example of angiomyolipoma with epithelial cyst.
  • PR expression in ovarian-like stroma cells and myoid tumor cells in a rare example of angiomyolipoma with epithelial cyst.

SynonymsEdit

AntibodiesEdit

Technical InfoEdit

Staining PatternEdit

  • Nuclear (like all steroid hormone receptors)

Expression in Normal TissuesEdit

Expression in Neoplastic EntitiesEdit

Expression in Neoplastic EntitiesEdit

BenignEdit
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments


Intermediate/Uncertain Malignant PotentialEdit
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments


MalignantEdit
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments
Breast carcinoma
Endometrial stromal sarcoma

Expression in Non-Neoplastic EntitiesEdit

Pertinent NegativesEdit

This antigen is typically NOT expressed by the following entities:

Practical Uses / PanelsEdit

  • Predictive marker in breast carcinoma[1]

Common PitfallsEdit

Related Links/Other ResourcesEdit

ReferencesEdit

  1. Hammond ME, Hayes DF, Dowsett M, Allred DC, Hagerty KL, Badve S, Fitzgibbons PL, Francis G, Goldstein NS, Hayes M, Hicks DG, Lester S, Love R, Mangu PB, McShane L, Miller K, Osborne CK, Paik S, Perlmutter J, Rhodes A, Sasano H, Schwartz JN, Sweep FC, Taube S, Torlakovic EE, Valenstein P, Viale G, Visscher D, Wheeler T, Williams RB, Wittliff JL, Wolff AC. American Society of Clinical Oncology/College of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer. Arch Pathol Lab Med. 2010;134(7):e48-72

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