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  • S100 protein immunostain (showing both nuclear and cytoplasmic positivity) in a cutaneous granular cell tumor. (http://commons.wikimedia.org/wiki/File:Granular_cell_tumor_(4)_S-100.JPG)
  • S100 protein expression in scattered dendritic cells in a high grade sarcoma. Such staining should not be interpreted as positive staining of tumor cells.
  • S100 protein expression in adipocytes.
  • S100 protein staining in sustentacular cells surrounding nests of paraganglioma cells. Note the paraganglioma cells are negative.
  • S100 protein staining in sustentacular cells surrounding nests of paraganglioma cells. Note the paraganglioma cells are negative.
  • S100 protein staining in sustentacular cells surrounding nests of paraganglioma cells. Note the paraganglioma cells are negative.
  • S100 protein staining in sustentacular cells surrounding nests of paraganglioma cells. Note the paraganglioma cells are negative.
  • Focal, patchy S100 protein expression in malginant peripheral nerve sheath tumor (MPNST).
  • Focal, patchy S100 protein expression in malginant peripheral nerve sheath tumor (MPNST).
  • Focal, patchy S100 protein expression in malginant peripheral nerve sheath tumor (MPNST).
  • thumb|S100 protein expression in a schwannoma. Note the hyalinized vessels.
  • thumb|S100 protein staining myoepithelial cells in the parotid gland.
  • thumb|S100 protein expression in myoepithelioma (parachordoma) of soft tissue.
  • thumb|S100 protein expression in myoepithelioma (parachordoma) of soft tissue.
  • thumb|S100 protein expression in myoepithelioma (parachordoma) of soft tissue.
  • thumb|S100 protein expression in myoepithelioma (parachordoma) of soft tissue.
  • thumb|S100 protein highlighting histiocytes with emperipolesis in Rosai-Dorfman Disease.
  • thumb|S100 protein highlighting histiocytes with emperipolesis in Rosai-Dorfman Disease.
  • thumb|S100 protein highlighting histiocytes with emperipolesis in Rosai-Dorfman Disease.
  • thumb|S100 protein highlighting histiocytes with emperipolesis in Rosai-Dorfman Disease.
  • thumb|S100 protein highlighting histiocytes with emperipolesis in Rosai-Dorfman Disease.
  • thumb|S100 protein highlighting histiocytes with emperipolesis in Rosai-Dorfman Disease.
  • thumb|S100 protein highlighting histiocytes with emperipolesis in Rosai-Dorfman Disease.
  • S100 expression in dendritic Langerhans cells (mid-epidermis) and melanocytes (basal) in the skin.
  • S100 expression in neurotropic desmoplastic melanoma.
  • S100 expression in neurotropic desmoplastic melanoma.
  • S100 expression in neurotropic desmoplastic melanoma.
  • S100 expression in neurotropic desmoplastic melanoma.
  • S100 expression in neurotropic desmoplastic melanoma.
  • S100 expression in neurotropic desmoplastic melanoma.
  • S100 expression in neurotropic desmoplastic melanoma.
  • S100 expression in neurotropic desmoplastic melanoma.
  • S100 expression in neurotropic desmoplastic melanoma.


SynonymsEdit

AntibodiesEdit

Technical InfoEdit

Staining PatternEdit

  • Nuclear AND cytoplasmic

Expression in Normal TissuesEdit

  • Melanocytes
  • Schwann cells
  • Langerhans cells
  • Other dendritic cells
  • Myoepithelial cells (some)

Expression in Neoplastic EntitiesEdit

BenignEdit
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments
Schwannoma 100%[1] 8/8[1]
Melanocytic nevi
Neurofibroma
Myoepithelioma 100%[2] 13/13[2]
Rosai-Dorfman Disease


Intermediate/Uncertain Malignant PotentialEdit
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments
Langerhans cell histiocytosis


MalignantEdit
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments
Chordoma
Melanoma 100%[3] 33/33[3]
Epithelioid Malignant Peripheral Nerve Sheath Tumor (MPNST)
Myoepithelial Carcinoma 100%[4] 25/25[4]

Expression in Non-Neoplastic EntitiesEdit

Pertinent NegativesEdit

This antigen is typically negative in the following:

  • Malignant peripheral nerve sheath tumor (MPNST). This is a common misunderstanding among pathologists. Approximately 50% of MPNST are totally negative for S100 protein. Those that are positive usually have only weak, focal, patchy staining. One exception is epithelioid MPNST, a tumor which is typically strongly S100 protein positive.
  • Only focally positive in meningioma with stronger cytoplasmic staining than nuclear staining (schwannoma is strongly and diffusely positive with nuclear staining predominating)[1]

Practical Uses / PanelsEdit

Common PitfallsEdit

ReferencesEdit

  1. 1.0 1.1 1.2 Am J Surg Pathol. 1986 Sep;10(9):640-9.
  2. 2.0 2.1 Hum Pathol. 2004 Jan;35(1):14-24.
  3. 3.0 3.1 Am J Surg Pathol. 2008 Mar;32(3):452-60.
  4. 4.0 4.1 Am J Surg Pathol. 2000 Jun;24(6):761-74.

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